Nimesulide
Nimesulide is a nonsteroidal anti-inflammatory drug which can reduce pain and reduce fever. Its has
been found effective in the treatment of acute pains, of symptomatic treatment of osteoarthritis, and in
primary dysmenorrhoea in adolescents and adults. Nimesulide’s mode of action is multifactorial and
has a fast onset of action. Its actions block the production of prostaglandins, a chemical associated
with pain, thereby relieving pain and inflammation. It is also used for period pains. it is not
recommended for long-term use in the treatment of chronic conditions such as arthritis because of the
increased risk of liver toxicity, including liver failure.
Nimesulide’s brand names vary a great deal around the world, for example, the most prominent
brands in Italy is called Nimesulene.
Nimesulide was first launched in Italy as Aulin and Mesulid in 1985 and is available in more than 50
countries worldwide, including among others France, Portugal, Greece, Switzerland, Belgium, Russia,
Thailand, and Brazil. Nimesulide has never been filed for FDA evaluation in the United States, where
it is not marketed.
Forms and Dosage
Nimesulide is sold in a variety of forms including tablets, powder for dissolution in water,
suppositories, mouth dissolving tablets, and topical gels. Nimesulide gets absorbed rapidly after oral
administration. The normal recommended dost for adults and adolescents over 12 years of age is
100mg twice a day.
The cost of Nimesulide
This medicine is manufactured and sold by an wide range of companies, manufacturers and labelers.
It is sold as a generic medication in India and in many other countries and tends to be inexpensive.
The retail price of tablet can range from 1 cent to 50 cents based on the brands being bought.
How does Nimesulide work?
Nimesulide starts working rapidly, with meaningful reductions in pain and inflammation within 15
minutes observed. its effects are the result of its complex mode of action, which targets a number of
key mediators of the inflammatory process such as: COX-2 mediated prostaglandins, free radicals,
proteolytic enzymes, and histamine. Clinical evidence is available to support a particularly good profile
in terms of gastrointestinal tolerability.
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