The potent parasympathetic alkaloid nicotine is widely used and highly addictive. It is naturally produced in the Nightshade family of plants, of which tobacco is a notable member, and additionally is present in concentrations of millionths of a per cent in the edible family of Solanaceae, of which potatoes, tomatoes, and aubergines are a part of. However, nicotine presence in Solanaceae is at diminished enough concentrations to have a biologically insignificant effect on humans. Traditionally nicotine has been consumed by humans for centuries and used as an antiherbivore chemical and insecticide. Currently, nicotine manufacturers and nicotine suppliers still grow and produce it, with distributors listing it for both sale and wholesale on the global marketplace at an assortment of price points. In recent decades more therapeutic uses for it as a medication have emerged, predominantly derived to treat symptoms involving nicotine withdrawal.
Method of action of nicotine:
Nicotine belongs to a group of drugs and pharmaceutical products that have a stimulatory effect on the autonomic ganglia, acting as an agonist at nicotinic cholinergic receptors. Causing stimulation of the neurons and ultimately blocking synaptic transmission. Specifically, in the brain nicotine binds to the nicotinic acetylcholine receptors situated on dopaminergic neurons in the cortico-limbic pathways, causing ion channels to open. This culminates in the release of dopamine into the synapse, which binds to its receptors causing the euphoric and addictive properties. Additionally, in the adrenal medulla nicotine binds to the acetylcholine receptors on chromaffin cells, triggering the release of epinephrine from intracellular vesicles into the bloodstream. This causes vasoconstriction, hypertension, increased heart rate, and increased blood sugar.
Form and dosage of nicotine:
The specific form is dependent on nicotine manufacturers and nicotine suppliers who have the product for order, as well as on the intended use. With typical forms indicated by manufacturers and distributors for use to treat nicotine withdrawal symptoms commonly being put on the for sale list as oromucosal powders, tablets, buccal methods, patches, and lozenges. Dosages are highly dependent on personal need and based on both delivery method and previous history of nicotine consumption. As such, relevant packaging and manufacturer’s instructions should be adhered to for use. With extra caution recommended if using an inhalation method and suffer from lung-related ailments, intranasal use and suffer from bronchial asthma, oral use and have gastritis, and finally transdermal use and have skin disorders or broken skin.
Nicotine on Pipelinepharma:
At the current time of writing, nicotine is available for B2B wholesale order online from our company marketplace. With a current search revealing 4 trusted global manufacturers and suppliers situated in countries including the European Union and India. These companies and their pharmaceutical products list have been verified by the Pipelinepharma team following strict quality control, minimising time wasted and improving sourcing efficiency.
Price of nicotine and how to buy:
The specific cost of nicotine remains confidential between both B2B parties on the online Pipelinepharma marketplace. However, if desired the manufacturers or distributors may choose to include the desired cost for their product alongside any supplementary technical information. This serves to expedite negation and subsequent transactions, by providing a price point reference on which to build. If a price is indicated, an ‘Accept’ button will be displayed alongside a ‘Negotiate’ button, with a ‘Get offer’ button being displayed in the absence of a listed price.