Nicergoline belongs to a class of drugs called semisynthetic ergot derivative and has a selective alpha-1A adrenergic receptor blocking property Nicergoline is used in Acute migraine headache and Raynaud's disease. It was in clinical use for over three decades in over fifty countries for conditions such as cerebral infarction, acute and chronic peripheral circulation disorders, vascular dementia, and Alzheimer’s disease and has been found to be beneficial in a variety of other conditions. An ergot derivative that has been used as a cerebral vasodilator and works with peripheral vascular disease. It also has been suggested to ameliorate cognitive deficits in cerebrovascular disease
Nicergoline is a vasoactive drug that is used in disorders related to blood vessels in the brain (including vascular dementia), eye (including macular degeneration, diabetic retinopathy), and other parts of the body (including Raynaud’s syndrome, migraine) that impair the blood flow of these organs and affect their functioning.
Nicergoline acts as a potent vasodilator (improves brain blood flow). On the cerebral level, it prompts a lowering of vascular resistance which shows an increase in arterial flow and stimulates the use of oxygen and glucose. Nicergoline also beneficially show improves blood circulation in the lungs and limbs and has been shown to inhibit blood platelet aggregation.
Nicergoline helps in the prevention and treatment of migraine headaches. Migraine headaches are thought to result from the dilatation of blood vessels in the head. Nicergoline works by constricting (narrowing) these blood vessels, thereby relieving migraine headaches.
Manufacturers market nicergoline under the brand name of Adavin, Circular, Ergobel. This medication is available in tablet and capsule dosage forms.
Do not take it to treat an acute attack of migraine. Some tips that may help avoid a migraine attack: Have your meals at the same time everyday Avoid bright lights and extreme temperatures Avoid loud music and noisy places Avoid chocolates, cheese, processed food, alcohol, and smoking Get sufficient sleep and avoid stress It should be taken at night-time before going to bed. It may cause sleepiness. Do not drive or do anything that requires mental focus until you know how Nicergoline affects you. Do not stop taking the medication suddenly as it can cause worsening headaches.
Before using this medication, the risk of taking the drug must be weighed against the benefits it provides. It is always recommended to consult a physician before taking Limecycline as this medication may interact with other drugs and health problems.
Fatigue, Nausea, Vomiting, Taste change, Agitation, Muscle pain, Restlessness, Hot flashes, Sleep disturbance, Dizziness is the common soe effects of this medication.
The approved storage conditions for Nicergoline are to store at a temperature of 25° C (77° F).
Wholesale Price of Nicergoline
The wholesale price of nicergoline costs around $ 7.60 for a set of 10 tablets and the per-unit cost available for as low as $ 0.76
Nicergoline - Mechanism of action
Nicergoline acts by inhibiting the postsynaptic alpha (1)-adrenoceptors on vascular smooth muscle. Which inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation. So, the mechanism of Nicergoline is to increase the vascular circulation in the brain, thereby enhancing the transmission of the nerve signals across the nerve fibers, which secretes acetylcholine as a neural transmitter.
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