Midodrine is an ethanolamine derivative that belongs to a class of medication called alpha-adrenergic agonists. It is used as a vasoconstrictor agent in the treatment of hypotension (low blood pressure) that causes severe dizziness or lightheadedness. Midodrine is known as a sympathomimetic that acts on the blood vessels to raise blood pressure.
This medication is used for certain patients who have symptoms of low blood pressure when standing, this condition is also known as Orthostatic Hypotension. This medication is used in people whose daily activities are considerably impaired by this condition, despite using standard clinical care.
Midodrine manufacturers sell this Drug under the Brand name of drug Amatine, ProAmatine, Orvaten. Midodrine is available in the dosage form of tablet which comes in 2.5 mg, 5 mg, 10 mg dosage strengths.
This medication is usually taken by mouth three times a day during daytime hours when the patient needs to be upright, pursuing the activities of daily living. The dosing should be at an interval of 3-4 hours between each dose. The suggested dosing schedule would be, shortly upon arising in the morning, midday and late afternoon no later than 6 P.M.
The usual recommended adult dose for hypotension is 10 mg midodrine taken by mouth 3 times a day. The three daily doses may be given at a 3-hour interval, if needed but not more frequently. This drug should not be given after the evening meal or less than 4 hours before bedtime. Midodrine is not recommended for children as safety and efficacy is not established.
Midodrine tablets are recommended to store at 20° C to 25° C (68° F - 77° F).
Wholesale Price of Midodrine
The wholesale price for 90 units of 2.5 mg Midodrine oral tablets is approximately $ 85.62 with per unit cost comes at $ 0.95. For the quantity of 50 tablets, it costs $ 45.52 with per unit cost $ 0.91
The wholesale price for 90 units of 5 mg Midodrine oral tablets is approximately $ 80.09 per unit cost comes at $ 0.89. For the quantity of 50 tablets, it costs $ 45.88 with per unit cost $ 0.92
The wholesale price for 30 units of 10 mg Midodrine oral tablets is approximately $ 36.56 - $ 45.00 per unit cost comes at $ 1.22 - $ 1.50. For the quantity of 50 tablets, it costs $ 68.67 with per unit cost $ 1.37
The lowest available wholesale price for the quantity of 1000 Midodrine 2.5 mg, 5 mg, 10 mg tablets are $ 7.50 with per unit costs as low as $ 0.01
Midodrine - Mechanism of Action
Midodrine is a direct-acting prodrug whose therapeutic effect upon oral administration is due to the formation of major metabolite, desglymidodrine. Desglymidodrine acts as an agonist at the alpha-adrenergic receptors expressed in the arteriolar and venous vasculature. Activation of alpha-adrenergic receptor signaling pathways leads to an increase in the vascular tone and elevation of blood pressure in patients with orthostatic hypotension.
Finding Midodrine Manufacturers and Suppliers
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