Metamizole belongs to a class of drugs called non-steroidal anti-inflammatory drugs (NSAID). It works by blocking the release of certain chemical messengers that cause pain and inflammation which normally causes redness and swelling.
It is primarily used for perioperative pain, acute injury, colic, cancer pain, other acute/chronic forms of pain and high fever unresponsive to other agents. This medication is used to reduce body temperature in fever with antipyretics nature.
Metamizole may be safer for the upper intestinal tract and kidneys than other NSAIDs and could alternatively be used for patients with an increased risk for stomach or renal problems.
Metamizole has anti-inflammatory agents which are non-steroidal in nature. Which show anti-inflammatory actions, and shows analgesic, antipyretic, and platelet-inhibitory actions.
Metamizole tablets and injection, Pro temporal liquid, and other drug products were associated with potentially fatal agranulocytosis. This medication was used in the past as a powerful painkiller and fever reducer.
Mainly this medication acts as a blocking the synthesis of prostaglandins with the inhibiting potency of cyclooxygenase, which converts arachidonic acid to the cyclic endoperoxides, precursors of prostaglandins. Inhibiting the production of prostaglandin synthesis accounts to showcase the significant analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Metamizole can be recommended for the treatment of cancer pain as an alternative to the other non-opioids either alone or in combination with opioids. Metamizole can be preferred over non-steroidal anti-inflammatory drugs due to the presumably favorable side effect profile in long-term use.
Before using metamizole, the risk of taking the drug must be weighed against the benefits it provides. It is always recommended to consult a physician before taking metamizole as this medication may interact with other drugs or health problems.
Manufacturer market Metamizole under the Brand name of Novalgin.
It is available in two forms Tablet and Injection which is administered as per the requirement of the patient and his/ her intensity of the disease or the pain.
Novalgin 500 mg Tablet and NOVALGIN 0.5% INJECTION is a pain-relieving medicine. It helps in relieving pain, inflammation, and fever in various conditions and disorders.
It is generally used in cases where oral administration is not suitable.
Metamizole should be stored in well-closed containers at a temperature below 25 C (77 F)
Wholesale Price of Metamizole
The wholesale price of metamizole is around $ 12 to $ 25 per kilogram.
Metamizole - Mechanism of Action
Metamizole converts arachidonate enzymes to prostaglandin H2 (PGH2), and a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets.
Metamizole sodium is an organic sodium salt of antipyrine substituted at C-4 by a methyl (sulfonate methyl) amino group, commonly it is used as a powerful analgesic and antipyretic. It has a role with a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antirheumatic drug, a peripheral nervous system drug, an antipyretic, a prodrug, and a cyclooxygenase 3 inhibitor. It also contains a metamizole (1-).
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