Metadoxine Manufacturers
Metadoxine belongs to a class of medication called antagonist of the serotonin receptors, which
are well known to be hepatoprotective medicines which means that they protect
the liver. Metadoxine is an antioxidant that primarily acts on free radicals.
This medication is used to treat certain chronic and acute alcohol intoxication which relieves neuro-psychological disorders. Metadoxine accelerates alcohol clearance from the blood and therefore, also helps in the treatment of fatty liver due to alcoholism. It acts by shielding the liver from getting attacked by chemical substances (harmful free radicals).
It also works by increasing alcohol elimination from the blood and tissues, thus preventing liver damage. Metadoxine is an iron pair salt of PCA also known as pyrrolidone carboxylate, the positive effect of metadoxine on ethanol metabolism is due to the fact that metadoxine maintains a normal level of alcohol dehydrogenase during chronic alcohol intake.
This drug in the long term protects the liver from damage against harmful chemicals known as
free radicals, thereby improving the overall health of the liver.
Metadoxine is not advised to be taken by pregnant and breastfeeding women. Consult your doctor before taking Metadoxine if you are planning to conceive, pregnant, or breastfeeding to prevent harmful effects on the baby. The most common side effects associated with Metadoxine include nausea, upset stomach and diarrhoea which are normally not seen in all the patients. Drink enough water or fluids to stay hydrated in case of severe diarrhea. Take it as
per dose and duration suggested by the doctor.Diarrhea may occur as a side effect.
Drink plenty of fluids and inform the doctor if diarrhea persists or if you find blood in your stools.
This drug is marketed with Brand Name: – Abisin, Alcotel, GanXin. The recommended dose is 0.5- 1 gram per day If it is IV or IM the recommended dosage is 300-600 mg per day Oral: Adults: 0.5-1 gm/day. Or 1 gm/day. Acute alcohol intoxication Intravenous/intramuscular: 300-600 mg/day. Alcoholic fatty liver, adjunct in acute and chronic liver diseases 300 mg/day.
Metadoxine may be taken with or without food as prescribed by the doctor. Take it in the dose and duration advised by the physician. Swallow the tablet whole; do not crush, break or chew. Metadoxine dose usually depends on the underlying disease one is being treated for and it also depends on total body weight.
Metadoxine is recommended to be stored at a room temperature 20° C to 25° C (68° F to 77° F)
Wholesale Price of Metadoxine
The wholesale price of Metadoxine 500 mg comes at £ 6.39 for 10 tablets.
Metadoxine -
Mechanism of action
As Metadoxine belongs to a class of antagonist of serotonin receptors it displays high liking towards the gamma-aminobutyric acid (GABA) transporter. In vitro enzymatic assay revealed that metadoxine reduced the activity of the GABA transaminase enzyme, responsible for the degradation of GABA. Electrophysiological studies also proved that metadoxine increased inhibitory GABAergic synaptic transmission through a presynaptic effect. It has not affected dopamine, norepinephrine or serotonin levels, methadone displays a novel mechanism of action as a monoamine-independent GABA modulator.
Finding Metadoxine Manufacturers and Suppliers
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