Mesna reduces the risk of hemorrhagic cystitis, a condition in which bladder inflammation
results in serious bleeding in people who receive ifosfamide, a form of chemotherapy. The
human body breaks down ifosfamide to form which harms the bladder. Mesna is a class of
medication called cytoprotectants which protect the bladder against the harmful effects of
some chemotherapy medications. However, it does not change the efficacy of ifosfamide.
Mesna is sold under the brand name Mesna and Mexna among others.
Asta Medica AG was given the first patent in 1988 and approved for sales in the United
States in 1988. Mesna features on the WHO's List of Essential Medicines.
Dosage Forms & Strengths and Administration
Mesna is available as an injectable solution in 100mg/mL and tablet of 400mg prescription.
In the Prevention of Ifosfamide Induced Hemorrhagic Cystitis, the recommended dose is 240
mg for m² for every 1.2 g for m² Ifosfamide dose, administered through an IVP 15 minutes
before and after that 4 & 8 hours after ifosfamide therapy is administered & 480 mg/m² of
Mesna tablets 2 & 6 hours after ifosfamide therapy. Mesna is also administered through
alternative IVP regimens, intermittent infusion, or continuous infusions. In the prevention of
Cyclophosphamide Induced Hemorrhagic Cystitis, the dose is 20% of cyclophosphamide
dose is injected, 4 and 8 hours after each dose of chemotherapy.
The price of Mesna
In the USA, the average retail cost for an injectable solution of 100 mg/mL is around $20 for
a supply of 10 milliliters for the consumers. The price of an Injectable Solution of 10
milliliters is between $20.08 – $65.19. the injection costs USD costs around USD1.1
for one 400 mg tablet.
How does Mesna work?
After injection, Mesna concentrates forms in the bladder. Acrolein accumulates in the
bladder after administration of chemotherapy and through a Michael addition. This forms a
conjugate with acrolein and other urotoxic metabolites inactivating the urotoxic compounds
to harmless metabolites. As a result of these actions, the patient's bladder is relaxed and
relief is provided.
Finding Mesna Manufacturers and Suppliers
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