Meropenem trihydrate as the name suggests is a hydrate from the carbapenem family of broad-
spectrum antibiotics. It treats a range of infections. These include meningitis, pneumonia, intra-
abdominal infection, sepsis, and anthrax. It is given by injection into a vein. It is also used in the
treatment of febrile neutropenia, a condition in patients with hematological malignancies and
cancer patients who are on anticancer therapies that suppress bone marrow formation. In
addition, It is also prescribed in the treatment of skin and skin structure infections, and in
combination with vaborbactam, It has been approved to treat complicated urinary tract infections
Meropenem trihydrate kills bacteria by blocking their ability to make a cell wall and more
resistant to breakdown by β-lactamase producing bacteria. Its spectrum of activity is effective
against many Gram-positive and Gram-negative bacteria including Pseudomonas and
anaerobic bacteria. However, Meropenem is more effective against Enterobacteriaceae and
less active against Gram-positive bacteria.
Meropenem is sold under the brand names Aronem, Aropen, Betanem among others.
Sumitomo Pharmaceuticals filed the first patent in the USA in 1983 and later approved it for sale
in 1996. For its efficacy and use worldwide in treating life-threatening conditions, it has earned a
place on the World Health Organization's List of Essential Medicines, which classifies it as
critically important for human medicine.
Dosage and administration
Meropenem trihydrate is sold as 500 mg powder for solution for injection or infusion containing
570.78 mg meropenem trihydrate, equal to 500 mg of anhydrous Meropenem.
In treating Severe pneumonia including hospital and ventilator-associated pneumonia,
Complicated skin and soft tissue infections, Complicated urinary tract infections and
Complicated intra-abdominal infections, Intra- and post-partum infections the dose is 500 mg or
1 g, the dose of treating Broncho-pulmonary infections in cystic fibrosis, Acute bacterial
meningitis is 2 g. for managing febrile neutropenic patients, the dose is set at 1 g. in all the
above cases, the standard gap between doses is about 8 hours. However, this dose is adjusted
for the infection, its severity, and the condition of the patient.
The price Meropenem trihydrate
In its ingredient form, with 98% purity, it costs around USD 70 for a supply of 10mg. In India, a
Meropenem Trihydrate Ip 1000 Mg, costs around USD 33 for a supply of 12 injections.
How does it work?
Meropenem actions penetrate bacterial cells readily. There it interferes with the synthesis of
vital cell wall components. The eventual result is cell death. The action involved for bactericidal
activity is delivered by inhibiting cell wall synthesis.
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