Macrogol also called polyethylene glycol is an osmotic laxative. It is used to treat constipation in
children and adults, to empty the bowels before a colonoscopy. Benefits usually occur within
three days. Macrogol 3350 is usually given with electrolytes, to give short term relief from
constipation and in long-term use for constipation caused by conditions like multiple sclerosis
and Parkinson's disease patients, caused by pharmaceutical drugs such as opioids and
anticholinergics. It is also used to irrigate the as part of the bowel preparation before surgery or
colonoscopy, including limited evidence for treating fecal impaction. It is also considered a
better option than lactulose and Tegaserod among those suffering from chronic constipation.
Some of the popular variants include 3350, 4000, and 6000, in which the number refers to its
average molecular mass and combining then given more control over the consistency of
molecular masses. Generally, it is only recommended to take this medicine for up to two weeks.
It is also safe during pregnancy. It is taken by mouth and provides relief by increasing the
amount of water in the stool.
Macrogol 3350 is sold under various brand names around the world including CosmoCol®,
Movicol®, Laxido®, Molaxole® among others.
Davis and Fordtran developed isoosmotic electrolyte-balanced solutions for whole gut lavage
with Macrogol 4000 in 1980 and was approved for medical use in the United States in 1999.
Since the expiry of its initial patent protection, now manufactured and sold as a generic OTC
medication around worldwide. In 2017, it was prescribed to more than 3 million US citizens.
Dosage and Administration
Macrogol 3350 is sold in sachets and oral solutions. Usually, it is the doctor who decided the
dosage, which is mostly in how many sachets are needed for each dose. The usual adult daily
dose is between 1-2 sachets, which can be increased to a maximum of 8 sachets daily. The
contents of the sachet are stirred into half 100-125 ml of water and consumed.
The price of Macrogol 3350
In the UK, the price of 20 sachets of generic brand cost the consumers £7.99, and an oral
solution of 250ml costs £6.99. in Italy, the price of 20 sachets is € 12.50.
How does it work?
Macrogol has osmotically laxative actions and passes through the gut without getting absorbed
into the body. It works by retaining water in the bowel instead of being absorbed into the body,
thus relieving it.
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