Ledipasvir
Ledipasvir is a medication used in the treatment of hepatitis C. The Ledipasvir/sofosbuvir
combination is a direct-acting antiviral agent, which directly interferes with virus replication
and can also treat other types of patients with different genotypes. Ledipasvir is an inhibitor
of NS5A, a Virus protein causing hepatitis C. Ledipasvir drug has effective in treatment-
naive and treatment experienced patients. The American Association for the Study of Liver
Diseases and the Infectious Diseases Society of America recommended Ledipasvir as a first
line therapy in combination with sofosbuvir in the treatment of various HCV genotypes.
Gilead Sciences developed Ledipasvir. After completing Phase III clinical trials in 2014
Gilead filed for U.S. approval of a Ledipasvir/sofosbuvir fixed-dose combination tablet for
genotype 1 hepatitis C and got the FDA approval for the combination product
Ledipasvir/sofosbuvir called Harvoni.
Forms and Dosage
Ledipasvir and sofosbuvir is sold as pellets and is swallowed without chewing or they can be
mixed with food. The dose is prepared by sprinkling the pellets on one or more spoonfuls of
cold non-acidic food like pudding or ice cream. The patient then has to take the mixture
within 30 minutes of sprinkling the pellets. It is recommended to continue with Ledipasvir
and sofosbuvir even the patient feels wells as the course last from 8 to 24 weeks depending
on patients and how well they responds to the medication.
The cost of Ledipasvir
In the USA, a consumer has to pay the wholesale price for Ledipasvir-sofosbuvir at $1125
per pill. The cost of a 8 week therapy is $63,000, 12 week therapy costs $95,000 and the Cost
of 24-week course of therapy is $189,000.
How does Ledipasvir work?
Ledipasvir inhibits an important a type of viral phosphoprotein, NS5A, this phosphoprotein is
essential for viral replication, assembly, and secretion. When taken, Ledipasvir binds to and
blocks the activity of the viral phosphoprotein resulting in the disruption of the viral
production, and inhibition of viral replication.
Finding Ledipasvir Manufacturers and Ledipasvir Suppliers
One of the fastest and easiest ways to find Ledipasvir manufacturers and Ledipasvir suppliers
is to make use of Pipelinepharma's global B2B online marketplace for medicines and other
pharmaceuticals.
Usually, finding trusted manufacturers and supplies of specific drugs like Ledipasvir can be a
time-consuming challenge, but with Pipelinepharma's simple search engine and network of
proven partners, the whole process becomes a lot easier.
All you need to do to get started is make use of our integrated search engine and start looking
for suppliers or manufacturers of Ledipasvir to work with. You can fine-tune your search
results using various filters too, letting you search for Ledipasvir from specific countries, for
example.
Manufacturers in India
Tecoland Corporation, Century Pharmaceuticals, Aspire Lifesciences Pvt Ltd, Deafarma,
Hetero Drugs Limited
In China
Hanways Chempharm Co., Limited , o Haoyuan Chemexpress Co.Ltd rporation
https://www.pharmacompass.com/listed-active-pharmaceutical-ingredients/ledipasvir
https://www.drugbank.ca/drugs/DB09027
https://en.wikipedia.org/wiki/Ledipasvir
https://pubchem.ncbi.nlm.nih.gov/compound/Ledipasvir
https://www.hepatitisc.uw.edu/page/treatment/drugs/ledipasvir-sofosbuvir
https://www.hepatitisc.uw.edu/page/treatment/drugs/ledipasvir-sofosbuvir
https://medlineplus.gov/druginfo/meds/a614051.html
https://www.webmd.com/drugs/2/drug-167104/ledipasvir-sofosbuvir-oral/details
https://www.journal-of-hepatology.eu/article/S0168-8278(18)30874-2/abstract
https://www.who.int/docs/default-source/essential-medicines/intellectual-property/ledipasvir-
report.pdf?sfvrsn=63bba21b_2