Iron sucrose injection is an iron replacement product most commonly used to treat iron
deficiency anemia in patients with chronic kidney disease in which damage is caused to the
kidneys which may worsen over time and may cause the kidneys to stop working.
The body produces red blood cells using iron. When the body is low on iron, it cannot
produce the number of normal red blood cells needed for good health. This iron-shortage
condition is called Iron Deficiency Anemia. The commonly prescribed treatment is
Intravenous iron sucrose injection. Iron sucrose replenishes the iron in the blood to foster red
blood cell production in patients of chronic kidney disease.
Iron sucrose is sold under the brand name Venofer amongst others.
Crookes Lab Ltd initially leads the Improvements relating to injectable iron preparations by
1953, they had filed the first patent. But it was Benger Lab Ltd, which created the first
therapeutic preparations of iron sucrose and was approved for use in Europe as early as the
1950s. however, the first patent for use in medicine was not approved by the FDA till the
Iron sucrose is available as a solution for injection for intravenous administration.
Iron sucrose contains 20 mg of iron per milliliter of solution. A typical adult patient is
prescribed an intake or dose of 600 mg of iron sucrose per week. This is administered in
separate doses of 200–300 mg. At a dose of 20 g per liter, patients experience an increase
in their hemoglobin levels. Each administration can take between fifteen to thirty minutes.
In India, the average cost of Iron sucrose injection ampoule is US$7 for a supply of 200 mg
and a tablet with the same medicine cost USD0.2 per tablet. However, due to the availability
of lot of manufacturers who can produce this product, this varies a lot.
How does it work?
Iron sucrose is an aqueous complex in sucrose of poly-nuclear iron hydroxide. After entering
the human body, Iron sucrose dissociates itself into iron and sucrose. This iron is then
transported as a complex with transferrin to target cells including erythroid precursor cells.
As the cells mature into red blood cells, the iron in the erythroid precursor cells gets
incorporated into hemoglobin.
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