Heparin Sodium Manufacturers
Heparin Sodium belongs to a class of drugs known as anticoagulants (blood thinners). Heparin Sodium is a naturally occurring anticoagulant released from mast cells. Heparin Sodium is indicated for prophylaxis and treatment of venous thrombosis and its extension, prevention of postoperative deep venous thrombosis and pulmonary embolism, and prevention of clotting in arterial and cardiac surgery.
This medication is also used to prevent embolisms in patients with atrial fibrillation and as adjunct antithrombin therapy in patients with unstable angina and or non-Q wave myocardial infarctions.
Heparin Sodium is also used to prevent clotting during dialysis and surgical procedures
Heparin Sodium is advised as a prescription product, generic prescription product as well as mixture product.
Heparin Sodium manufacturers sell this Drug under the Brand name of the drug Hep-Lock, Hepalean, Calcilean. This drug is available in dosage form of injections which is administered intravenously and subcutaneously and comes in various dosage strengths like 10 [USP’U]/1 mL, 100 [USP’U]/1 mL. There is no pill form for Heparin Sodium.
Before using this medication, the risk of taking the drug must be weighed against the benefits it provides. It is always recommended to consult a physician before taking heparin sodium as this medication may interact with other drugs.
The recommended initial intermittent dose of Heparin Sodium for therapeutic anticoagulant effect is 10,000 units which is administered intravenously and after the initial dose, 5,000 to 10,000 units every 4-6 hours.
For continuous intravenous infusion, the initial recommended dose is 5000 units by intravenous injection and continuous infusion of 20,000 to 40,000 units every 24 hours. And for patients undergoing total body perfusion for open-heart surgery should receive an initial dose of not less than 150 units of heparin sodium per kilogram of body weight. Frequently, a dose of 300 units per kilogram is used for procedures estimated to last less than 60 minutes or 400 units per kilogram for those estimated to last longer than 60 minutes.
Heparin Sodium injections are recommended to store at 20° C to 25° C (68° F to 77° F). Should avoid excessive heat.
Wholesale Price of Heparin Sodium
The wholesale price for 50 units of 1000 units/mL heparin injectable solution is $ 209 with per unit cost comes at as low as $ 4.18
The cost for 10 units of 5000 units/mL heparin injectable solution is around $ 59 for a supply of 10 milliliters.
Heparin Sodium - Mechanism of Action
Heparin interacts with the naturally occurring plasma protein, Antithrombin III, to induce a conformational change, which markedly enhances the serine protease activity of Antithrombin III, thereby inhibiting the activated coagulation factors involved in the clotting sequence, particularly Xa and IIa. Small amounts of heparin inhibit Factor Xa, and larger amounts inhibit thrombin (Factor IIa). The antithrombotic effect of heparin is well correlated to the inhibition of factor Xa. Heparin also prevents the formation of a stable fibrin clot by inhibiting the activation of the fibrin stabilizing factor.
Finding Heparin Sodium Manufacturers and Suppliers
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