Estradiol is an estrogen medication that is widely used in birth control pills in combination with Progestins. In the past, Estradiol was earlier prescribed to treat various indications such as menopausal symptoms, gynecological disorders, and certain hormone-sensitive cancers. Estradiol is an agonist of the estrogen receptors, the biological target of estrogens like estradiol. It is a synthetic derivative of estradiol, a natural estrogen but differs from it in various ways. Compared to estradiol, Estradiol has greatly improved bioavailability when taken by mouth, in addition to being more resistant to metabolism. It also shows relatively better efficacy in certain parts of the body like the liver and uterus. These differences make Estradiol more favorable for use in birth control pills than estradiol. However, high usage can Increase the risk of blood clots and certain other rare adverse side effects.
Estradiol was the first orally active synthetic estrogen and was described in 1938 by Hans Harloff Inhoffen and Walter Hohlweg of Schering AG in Berlin. Schering got the first approval from the FDA in 1943. It is marketed under the brand name Estinyl. However, it only started being used as birth control pills later in the 1960s. Today, Estradiol is the exclusive estrogen used for this purpose, making it one of if not the most widely used estrogens. The FDA withdrew approval of Estinyl effective in 2004 at the request of Schering, which had discontinued marketing it. However, given the obvious societal benefits of the medicine, It is manufactured and sold under several brand names by global and local manufacturers and labelers.
How does Estradiol work?
Estradiol is a synthetic estrogenic compound. The use of estrogens has several effects on the body including reduced bone density. Combined oral contraceptives suppress ovulation by thickening the cervical mucus to prevent sperm from traveling, and preventing changes in the endometrium required in the implantation of a fertilized egg. Estradiol was previously available by itself under the brand name Estinyl in the form of 0.02, 0.05, and 0.5 mg (20, 50, and 500 µg) tablets. It is usually taken by mouth but is also used as a patch and vaginal ring. Estradiol is available in combination with progestin as a transdermal contraceptive patch and as a contraceptive vaginal ring. In addition, there is a single preparation containing very low doses of Estradiol plus progestin in an oral tablet that remains in use for menopausal hormone therapy.
The Wholesale Price of Estradiol
For bulk industrial usage, the powder form is sold commercially at about USD 500. However, one of the commonly sold brands sells for about USD 100 for a monthly supply of 30 tablets. In developing countries, the wholesale price of imported powder is can vary between USD 15-30 due to domestic manufacturers. Estradiol is available for sale from a variety of Estradiol vendors at a range of costs. Prices are only valid for consumers who pay cash and do not apply to insurance coverage. Estradiol suppliers, on the whole, are in favor of patient aid initiatives. This cost may differ among dealers.
Manufacturers and Supplier for Estradiol
Pipelinepharma's worldwide B2B online marketplace for medications and other pharmaceuticals is one of the quickest and easiest methods to locate Estradiol manufacturers and suppliers. Finding reliable manufacturers and suppliers of specialized pharmaceuticals like Estradiol can be time-consuming, but Pipelinepharma's simple search engine and network of trusted partners make the process a lot easier. To get started, simply use our built-in search engine to begin looking for Estradiol suppliers or manufacturers with whom to collaborate. You can also use other criteria to fine-tune your search results, allowing you to look for Estradiol from a certain location.
Navigating Our Pharmaceutical Marketplace
Being a global B2B pharmaceutical online marketplace, Pipelinepharma is structured to simplify pharmaceutical deals by providing you with an intuitive interface that is easy to engage with. The selection of Estradiol offerings can be narrowed down with the use of filters and easily weighed against one another according to medication prices and commercial terms. The advanced filters help you filter out the countries for Estradiol manufacturers and Estradiol suppliers that you are looking for. These also enable you to check the dossier status of Estradiol, and the GMP approvals of the different variants of Estradiol. Also, each manufacturer or supplier product description contains essential information about Estradiol including clinical data, stability zones, countries where Estradiol is already registered in. Manufacturers also have special, and delivery terms.
Establishing Commercial Ties
If you are a pharmaceutical licensing company or a distributor you can enter into deals or negotiations over Estradiol offers with manufacturing companies after completing the free registration process and joining our online marketplace. This helps to ensure that you conclude the pharmaceutical deal at a reasonable cost and achieve the best cost/benefit ratio for your company while bypassing lengthy sourcing, negotiation, and order process. Once you have finalized a deal, you can look forward to a long-lasting business relationship with the manufacturers or suppliers. This way, the marketplace allows you as a distributor to skip the process of making a list of product manufacturers every time you are looking for in-licensing or distribution deals.
To keep up to the quality standards other than the Good Manufacturing Practice approvals that Estradiol manufacturers list has, we qualify their companies before they are boarded on the platform. This allows us to screen Estradiol manufacturers for the quality of the pharmaceutical products’ dossiers and protect against the risk of possible malpractices.