Erythropoietin is a therapeutic agent used in treating anemia resulting from chronic kidney
disease and myelodysplasia, from the treatment of cancer like chemotherapy and radiation. It
is produced by recombinant DNA technology in mammalian cell culture. It treats anemia by
increasing the red blood cell count in people with long-term serious chronic kidney failure,
or people getting treated for HIV with zidovudine, and chemotherapy for cancer that does not
involve the bone marrow or blood cells.
Erythropoietin Alfa is given to anemic patients to reduce the need for blood transfusions
before some kinds of planned surgeries with a high risk of blood loss Epoetin alfa actions amek
the bone marrow produces more red blood cells.
Epoetin alfa is human erythropoietin that was authorized by the European Medicines
Agency in 2007 to stimulate erythropoiesis and to treat anemia, associated with chronic
kidney failure and cancer chemotherapy. Amgen manufactured is under the name Epogen,
J& J sells it as Procrit, pursuant to a product license agreement.
Dosage Forms & administration
Epoetin alfa is sold as an injectable solution in concentrations from 2000 units/mL, 3000
units/mL, 4000 units/MLM 10,000 units/mL, 20,000 units/mL and 40,000 units/mL. in the
treatment of Patients with CKD on dialysis, the treatment is initiated when hemoglobin level
drops below <10 g/dL. If its level approaches or >11 g/dL, the user can reduce the dose. The
initial dose is 50-100 units/kg, given through an IV, three times a day. In the treatment of
anemia due to HIV treatment with zidovudine at <4200 mg for the week are given the endogenous
serum of <500 milliunits/mL followed by 100 units/kg, 3 times weekly. If HBG levels don’t
improve in 8 weeks, the dose is increased by 50-100 units for kg, every 1-2 months until
hemoglobin reaches a level sufficient to avoid RBC transfusions. This medication should be
taken closely in relation to the HBG levels in consultation with your doctors.
The Cost of Epoetin Alfa
For years, this medicine cost the US Government, nearly USD 2 billion in making this
medicine affordable. However, the cost has now come down, wherein in the USA, The
consumer cost for the injectable solution of 2000 units/mL is USD $356 for a supply of 10
milliliters. However, it is much cheaper in the developing world. In India, a vial containing
4000IU Inj costs only around USD 12 and can be as high as USD 20.
How does Epoetin Alfa Work?
Erythropoietin is a glycoprotein. Its role is to regulate the production of red blood cells by
stimulating the division and differentiation of committed erythroid progenitor cells in the
bone marrow. Epoetin Alfa is made using recombinant DNA technology in mammalian cell
culture. It works by increasing the red blood cells.
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