ERYTHROMYCIN STEARATE

Erythromycin Stearate is an antibiotic. It treats and prevents a wide variety of bacterial infections. Erythromycin Stearate inhibits the growth of drug-resistant bacteria, maintains the effectiveness of Erythrocin Stearate Film-coated tablets and other antibacterial drugs. It should be used to treat or prevent infections that are proven strong susceptibility to this medicine. It is indicated in the treatment of mild to moderate degree Upper and lower respiratory tract infections caused by Streptococcus pyogenes or Streptococcus pneumonia or Haemophilus influenza. It also used to treat Listeriosis caused by Listeria monocytogenes, Respiratory tract infections caused by Mycoplasma pneumonia, mild to moderately severe Skin and skin structure infections caused by Streptococcus pyogenes or Staphylococcus aureus, whooping cough caused by Bordetella pertussis, Diphtheria, Erythrasma, Intestinal amebiasis, Acute Pelvic Inflammatory Disease. Erythromycin Stearate is sold as Erythrocin Stearate amongst others. Abbott Laboratories first filed for a patent in the 70s and was given the go-ahead in 1981. Since then the original patent has expired.

DOSAGE AND ADMINISTRATION

Erythromycin Stearate is sold as film-coated tablets. However, the efficacy is best, when the optimal serum levels of erythromycin are reached it is taken in the fasting state or immediately before meals. the initial adult dose is usually 250 mg, taken every 6 hours or 500 mg, taken every 12 hours. Dosage can be increased in the intervals of 4g. In treating children, the Age, weight, and severity of the infection determine the dosage. They are normally given 30 to 50 mg per kilo per day, in equally divided doses. For curing streptococcal infections of the upper respiratory tract the dosage is given for at least ten days. in treating Conjunctivitis of the Newborn Caused by Chlamydia trachomatis, the oral suspension of 50mg per kilo per day, in 4 divided doses for at least 2 weeks. In the treatment of Pneumonia of Infancy Caused by Chlamydia trachomatis, the dose is suspension taken 50 per kilo per day, in four divided doses for at least 3 weeks. For treating Urogenital Infections During Pregnancy Due to Chlamydia Trachomatis, a dose of 500 mg is taken orally every 8 hours on an empty stomach for at least 7 days.

The cost of ERYTHROMYCIN STEARATE

In the USA, the consumers have around $352 for a supply of 30 oral tablets of 250 mg. As with most critical medicines, this medicine made in developing countries by generic drug makers has reduced the end cost significantly. In India, consumers can buy 10 tablets for as low as USD 1.1.

How does Erythromycin Stearate Work?

Erythromycin binding 50S ribosomal subunits of susceptible organisms thus inhibiting protein synthesis. It creates resistance by modifying the 23S rRNA in the 50S ribosomal subunit. It causes insensitivity while efflux can is significant. Overall resulting in the prevention of bacterial protein synthesis. It may also have bacteriostatic or bactericidal actions in different concentrations at the site of infection and the susceptibility of the infecting organism.

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