What is Doxepin?
Doxepin is an antidepressant medication that is primarily used to treat depression, anxiety and difficulties sleeping. These drug manufacturers produce and suppliers market the drug as 10mg, 25mg and 50mg, 75mg, 100mg, and 150mg tablets as well as in the form of oral suspensions. The drug is also approved as an anti-itching agent and is also available as a constituent in topical formulations, such as creams and lotions. The developer and earliest manufacturer was Pfizer, who, following FDA approval in 1969 distributed it under the trade name Sinequan. As of now, the drug is available in multiple major markets, including Australia, the United Kingdom, and the EU. What is more, these medications are widely prescribed, with the U.S. alone registering over 2 million prescriptions of the drug yearly. These drug suppliers and distributors market both generic and trade name formulations of the drug. Buyers are advised that online sellers may attempt to market fraudulent versions of the generic drug, whereas Pipeline Pharma, through its pre-auditing and quality control procedures ensures that only verified pharmaceutical manufacturers and wholesalers enter our online marketplace, offering you a risk-free B2B pharmaceutical sales platform. Alternatives to this pharmaceutical remedy are other tricyclic antidepressant class drugs such as amitriptyline, clomipramine, desipramine, imipramine, nortriptyline, protriptyline, and trimipramine.
Doxepin is moderately absorbed after oral administration, with a bioavailability of 30%. The median peak concentration of this drug is 8.8-45.8 ng/ml and occurs 3.5 hours after treatment. Its absorption is boosted when a high-fat meal is consumed at the same time.
It is extensively metabolized, yielding N-desmethyldoxepin, a physiologically active metabolite, as well as several inert metabolites. The administered dose is accounted for by 55-87 percent of the first-pass metabolism. The secondary metabolism is then fueled by the conversion of N-desmethyldoxepin to its glucuronide conjugates.
The elimination profile of this pharmaceutical medicine is presented as biphasic.3 It is excreted in the urine mainly in the form of glucuronide conjugates. Less than 3% of its dose is excreted in the urine as a parent compound or nordoxepin. The mean elimination half-life is reported to be 15 hours.
This pharmaceutical medicine is excreted in breast milk and may harm a nursing newborn. It is not advised to breastfeed while using this medication.
Arbutamine, thyroid supplements, anticholinergic medications (such as Belladonna Alkaloids), and central-acting pharmaceuticals to treat high blood pressure are examples of products that may interact with this medication (such as Clonidine, Guanabenz).
Drowsiness, dizziness, dry mouth, blurred vision, constipation, or difficulty urinating are all possible side effects related to this drug. Some of the serious side effects that necessitate immediate medical treatment include persistent heartburn, mental/mood problems (such as anxiety, agitation, and disorientation), shaking, and severe stomach/abdominal pain.
This drug should be taken only when necessary during pregnancy. Babies born to moms who used this medicine in the last three months of their pregnancy may experience withdrawal symptoms such as feeding/breathing difficulty, seizures, muscular rigidity, or persistent wailing. If you detect any of these symptoms in your infant, contact your doctor right once.
The precise mechanism of action of Doxepin is unknown. It is, on the other hand, is a specific histamine H1 receptor blocker. This action on histamine receptors suggests efficacy in skin disorders.
Retail prices for Doxepin medications vary depending on manufacturer and supplier pricing as well as the concentration of the active ingredient. The cost per 100 (25mg) tablets fall into an approximate range of 20,00 EUR to 35 EUR.
Being a global B2B pharmaceutical online marketplace, Pipelinepharma is structured to simplify pharmaceutical deals by providing you with an intuitive interface that is easy to engage with. The selection of Doxepin offerings can be narrowed down with the use of filters and easily weighed against one another according to medication prices and commercial terms. The advanced filters help you filter out the countries for this substance manufacturers and this substance suppliers that you are looking for. These also enable you to check the dossier status of this medicine, and the GMP approvals of the different variants of this drug. Also, each manufacturer or supplier product description contains essential information about this substance including clinical data, stability zones, countries where this pharmaceutical drug is already registered in. Manufacturers also have special, and delivery terms.
If you are a pharmaceutical licensing company or a distributor you can enter into deals or negotiations over this medicine offer with manufacturing companies after completing the free registration process and joining our online marketplace. This helps to ensure that you conclude the pharmaceutical deal at a reasonable cost and achieve the best cost/benefit ratio for your company while bypassing lengthy sourcing, negotiation, and ordering process. Once you have finalized a deal, you can look forward to a long-lasting business relationship with the manufacturers or suppliers. This way, the marketplace allows you as a distributor to skip the process of shortlisting product manufacturers every time you are looking for in-licensing or distribution deals.
To keep up to the quality standards other than Good Manufacturing Practice approvals that this medicine manufacturers list has, we qualify their companies before they are boarded on the platform. This allows us to screen Doxepin manufacturers for the quality of the pharmaceutical products’ dossiers and protect against the risk of possible malpractices.