Dosulepin is a tricyclic depression that is generally used only in patients who have failed to respond to other treatments due to its propensity for harm. Dosulepin, originally known as dothiepin. Its anxiolytic characteristics that is used throughout South Africa as well as Australia, Europe, and South Asia, and New Zealand. Due to its limited therapeutic index and high toxicity in overdose, it is still not approved by the FDA. It increases accessible neurotransmitter levels at the synaptic cleft by inhibiting biogenic amine reuptake.
Dosulepin should only be used in patients who are allergic or non-responsive to other antidepressant treatments. Dosulepin is a thiol derivative of Amitriptyline that seems to have central sedative, antihistamine, and anticholinergic characteristics, comparable to that of Amitriptyline. Its hydrochloride version is commonly used as an active component in a variety of medication compositions.
How does Dosulepin Work?
Dosulepin boosts the unbound levels of noradrenaline and 5HT in the synaptic cleft by binding to noradrenaline transporter (NAT) and serotonin transporter (SERT) in an equipotent way and blocking reuptake function. The primary metabolite, northiaden, has been demonstrated to be a more powerful blocker of noradrenaline absorption than that of the active ingredient.
Dosulepin interacts to muscarinic acetylcholine receptors as well, causing antimuscarinic side effects like dry mouth. It produces a sedative effect by acting as an antagonist at histamine type 1 (H1) channels. Northiaden, dothiepin sulphoxide, and northiaden sulphoxide are primary metabolites that may interact to 5HT, 2, and H1 sites, however with lower affinity than the parent drug.
The Cost of Dosulepin
This drug is available from a range of manufacturers and drugstores at various rates. Depending on the drugstore you visit, Dosulepin oral tablet 30 mg costs roughly $24 for a supply of 100 tablets. Pharmaceutical corporations generally support patient assistance programs, which provide free or subsidized drugs to low-income, unemployed, or poorly patients.
Navigating our Pharmaceutical Marketplace
Being a global B2B pharmaceutical online marketplace, Pipelinepharma is structured to simplify pharmaceutical deals by providing you with an intuitive interface that is easy to engage with. The selection of Dosulepin offerings can be narrowed down with the use of filters and easily weighed against one another according to medication prices and commercial terms. The advanced filters help you filter out the countries for Dosulepin manufacturers and Dosulepin suppliers that you are looking for. These also enable you to check the dossier status of this medicine, and the GMP approvals of the different variants of Dosulepin. Also, each manufacturer or supplier product description contains essential information about this substance including clinical data, stability zones, countries where Dosulepin is already registered in. Manufacturers also have special, and delivery terms.
Establishing Commercial Ties
If you are a pharmaceutical licensing company or a distributor you can enter into deals or negotiations over these medicine offers with manufacturing companies after completing the free registration process and joining our online marketplace. This helps to ensure that you conclude the pharmaceutical deal at a reasonable cost and achieve the best cost/benefit ratio for your company while bypassing lengthy sourcing, negotiation, and ordering process. Once you have finalized a deal, you can look forward to a long-lasting business relationship with the manufacturers or suppliers. This way, the marketplace allows you as a distributor to skip the process of shortlisting product manufacturers every time you are looking for in-licensing or distribution deals.
To keep up to the quality standards other than Good Manufacturing Practice approvals that this medicine manufacturers list has, we qualify their companies before they are boarded on the platform. This allows us to screen Dosulepin manufacturers for the quality of the pharmaceutical products’ dossiers and protect against the risk of possible malpractices.