Diosmectite is a natural silicate of Aluminum & Magnesium. It is used as an intestinal
adsorbent in the treatment of several diseases affecting the gastrointestinal tract, including
infectious and non-infectious acute and chronic diarrhoea. It is also used in the treatment of
irritable bowel syndrome diarrhea subtype. Other uses of Diosmectite include chronic
diarrhea caused by radiation or chemotherapy-induced, and AIDS-associated chronic
Diosmectite is sold under the brand names Smecta & Smecdral to name a few.
Ipsen Pharma SAS owns the current patent of this medicine, the USFDA granted the approval
for sales in 2015 in the USA, it is marketed by many companies on behalf of Ipsen Pharma.
Forms and Dosage:
Diosmectite is insoluble in water. Diosmectite’s adjuvant to rehydration therapy for acute
infectious diarrhoea in children reduces the duration of Diarrhoea by a full day and it may
increase cure rate by the third day. Not only does it reduce stool output, but it also has no
effect on hospitalization rates or need for intravenous therapy. In the treatment of acute
diarrhea in infants and children up to 1 year, the recommended dose is 2 packets a day for 3
days, followed by 1 packet a day. For kids older than 1 year and older, the recommended
dose is 4 packets a day for 3 days, followed by 2 packets a day. Whereas in adults, the
standard dose on average is 3 packets a day. Doctors can double the dose as per the need.
The cost of Diosmectite
In Malaysia, the consumers pay 100 ringitt for a supply for 10 sachets of the oral solution.
Whereas the 3mg product sells for 33USD in France. In India, the 30 ml syrup manufactured
by a generic formulation costs 0.06 USD.
How does it work?
Diosmectite does not get absorbed in the intestine but it can adsorb eight times its own weight
of water, thereby diminishing free stool water. Diosmectite can also adsorbs toxins, bacteria,
and rotavirus, preventing adherence to intestinal membranes. Diosmectite is effective in
improving stool consistency because of its ability to absorb bacteria, viruses and toxins as
well as strengthening the intestinal mucus barrier to reduce luminal antigens passing through
the mucus barrier which in turn helps to reduce inflammation. Efficacy findings on
Diosmectite indicate that it exerts an anti-diarrhoeal effect by inhibiting viral replication and
the expression of NSP4.
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