Diltiazem treats high blood pressure or hypertension and prevents episodes of chest pain
also called Angina. Lowering high blood pressure helps prevent strokes, heart attacks, and
kidney problems. Regular use of Diltiazem leads to a significant decrease in the number and
severity and the number of episodes of chest pain from angina. It may help increase your
ability to exercise.
Diltiazem is used to prevent chest pain (angina). It may help to increase your ability to
exercise and decrease how often you may get angina attacks. Diltiazem is called a calcium
channel blocker. Diltiazem actions relax blood vessels in the body and heart. This lowers the
heart rate so that blood can flow more easily. This results in less stress on the heart, making
it less susceptible to cardiovascular issues. Diltiazem is called a calcium channel blocker.
Diltiazem is sold under the brand names such as Cardizem, Cardizem LA, Cartia XT among
Bayer AG started the development of calcium channel blockers in the 1970s. Diltiazem is
one of the several other calcium channel blockers developed by them in the 70s. Valeant
International Bermuda is the current assignee who has made a formulation suitable for one a
Dosage and administration
Diltiazem is available as tablets. These are to be swallowed whole. The users should not
split, crush, or chew the tablet. It is sold in increasing strengths of 30-mg,60-mg, 90-mg, 120-
mg scored tablets and are supplied in bottles of 100 tablets.
Dosage must be adjusted to each patient's needs. The initial starting is 30 mg, given four
times daily, before meals and at bedtime. If there is a need, does increase should happen
gradually, so it is administered in divided doses, three or four times daily. This is done at 1-to
2-day intervals till the users get an optimum response. The average optimum dosage range
is between 180 to 360 mg/day.
The cost of Diltiazem
In the USA, the consumers have to pay an average retail price of $28.09 for 90 tablets of
30mg. whereas in India, the cost of 90 tablets is only USD 6.
How does Diltiazem work?
It is not known exactly how its antianginal action function, however, it is described that it
works on Angina through a Coronary Artery Spasm. It is a potent dilator of both epicardial
and subendocardial coronary arteries. It induces Spontaneous and ergonovine-induced
coronary artery spasms. In users with Exertional Angina, it increases users' exercise
tolerance, because it can reduce myocardial oxygen demand. This is accomplished via
reductions in heart rate and systemic blood pressure at submaximal and maximal exercise
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