Diltiazem

Diltiazem treats high blood pressure or hypertension and prevents episodes of chest pain also called Angina. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Regular use of Diltiazem leads to a significant decrease in the number and severity and the number of episodes of chest pain from angina. It may help increase your ability to exercise. Diltiazem is used to prevent chest pain (angina). It may help to increase your ability to exercise and decrease how often you may get angina attacks. Diltiazem is called a calcium channel blocker. Diltiazem actions relax blood vessels in the body and heart. This lowers the heart rate so that blood can flow more easily. This results in less stress on the heart, making it less susceptible to cardiovascular issues. Diltiazem is called a calcium channel blocker. Diltiazem is sold under the brand names such as Cardizem, Cardizem LA, Cartia XT among others. Bayer AG started the development of calcium channel blockers in the 1970s. Diltiazem is one of the several other calcium channel blockers developed by them in the 70s. Valeant International Bermuda is the current assignee who has made a formulation suitable for one a day administration

Dosage and administration

Diltiazem is available as tablets. These are to be swallowed whole. The users should not split, crush, or chew the tablet. It is sold in increasing strengths of 30-mg,60-mg, 90-mg, 120- mg scored tablets and are supplied in bottles of 100 tablets. Dosage must be adjusted to each patient's needs. The initial starting is 30 mg, given four times daily, before meals and at bedtime. If there is a need, does increase should happen gradually, so it is administered in divided doses, three or four times daily. This is done at 1-to 2-day intervals till the users get an optimum response. The average optimum dosage range is between 180 to 360 mg/day.

The cost of Diltiazem

In the USA, the consumers have to pay an average retail price of $28.09 for 90 tablets of 30mg. whereas in India, the cost of 90 tablets is only USD 6.

How does Diltiazem work?

It is not known exactly how its antianginal action function, however, it is described that it works on Angina through a Coronary Artery Spasm. It is a potent dilator of both epicardial and subendocardial coronary arteries. It induces Spontaneous and ergonovine-induced coronary artery spasms. In users with Exertional Angina, it increases users' exercise tolerance, because it can reduce myocardial oxygen demand. This is accomplished via reductions in heart rate and systemic blood pressure at submaximal and maximal exercise workloads.

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