Actovegin is a highly concentrated and filtered extract obtained from calf blood. It is used to enhances aerobic oxidation to improve the absorption of glucose and oxygen uptake in tissue. This enhances physical performance and stamina in humans. Actovegin is useful in treating muscle injuries, for improving circulation and nutrition disturbances, grafting of skin & burns, and wound-healing impairment and investigated for polyneuropathy in diabetes, and for stroke. Actovegin concentrate is sold under the brand names ACTOVEGIN & SOLCOSERLI to name a few. Nycomed Austria GmbH filed for the first patent on this Actovegin concentrate in 2009 and was granted the permission in 2017 for EU. This medicine is not approved for USFDA or for sales in the USA. Local use of this extract is allowed in Canada and Sweden. Athletes have been using it for performance enhancement.
Actovegin is administered intravenously, including infusion, intra-arterially, and also intramuscularly, but injecting it into the block track is prohibited. It is injected slowly at the rate of 2 ml a minute, as there is a risk of serious anaphylactic reactions so the patient is tested for allergy before the injections.
It is sold as tablets and ampoules in 200mg & 400mg and 2ml, 5ml, and 10ml ampoules. In the international market, five ampoules of Actovegin 10 ml costs $69.00, and a supply of 50 tablets of Actovegin 200 mg, costs USD $62.00.
Actovegin improves the transport of glucose over a plasma membrane, while also improving the uptake of oxygen by tissues. this causes aerobic oxidation giving cells access to more energy and potentially enhancing their function. It also has high concentrations and volume of superoxide dismutase enzymes and magnesium. It helps capillaries improve circulation through neogenic enhancement mechanisms in blood vessels.
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