Dapsone is a synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties. Dapsone belongs to a class of drugs known as sulfones. Dapsone is a sulfonamide related drug used for the therapy of leprosy and dermatitis herpetiformis.
Dapsone is the principal drug in multidrug regimen recommended by the World Health Organization for the treatment of leprosy. As an anti - infective agent, it is also used for treating malaria and recently for Pneumocystis carinii pneumonia in AIDS patients. This medication along with other drugs also used to treat Hansen’s disease.
Dapsone is advised as a prescription product as well as generic prescription product.
Dapsone is marketed by manufacturers under the Brand name of Aczone, Avlosulfon. It is issued on prescription only.
This medication is available in the dosage form of Gel and Tablet. The Gel form is available in a dosage strength of 50 mg / 1g and 75 mg / 1g while tablets are available in 25 mg and 100 mg. Gel is applied topically and tablets are for oral use which can be taken with or without food, usually once daily or as directed by a physician.
For Dermatitis Herpetiformis, the dosage should be individually titrated starting in adults with 50mg daily and correspondingly smaller doses in children, if control over the treatment is not achieved within the range of 50 - 300 mg daily, higher doses may be tried but the dosage should be reduced to a minimum maintenance level as soon as possible.
The recommended dose of Dapsone in patients with leprosy and borderline leprosy is 100 mg daily with the co-administration of other drugs.
Dapsone gel 7.5 % is available in the US and Australia for the topical treatment of acne. The gel is applied once daily.
The recommended storage conditions for Dapsone is to store at 20° C - 25° C (68° F - 77° F) away from light, moisture and heat and Protect from freezing.
Wholesale Price of Dapsone
The wholesale price of Dapsone oral tablet 25 mg is around $ 51 for a supply of 30 tablets with a per unit cost of $ 1.70 depending up on the pharmacy, the lowest available per unit cost is $ 1.64 for a set of 100 tablets. The per unit price of Dapsone 100 mg oral tablet is $ 1.98 and for a set of 100 tablets it costs around $ 198.
The 5 % Dapsone Gel per unit costs around $ 5.52.
Dapsone - Mechanism of Action
Dapsone is a competitive inhibitor of para-amino benzoic acid (PABA), a critical substrate for folate biosynthesis. Dapsone blocks the condensation of PABA and 7,8-dihydro-6-hydroxymethylpterin-pyrophosphate from forming 7,8-dihydrofolic acid. The key enzyme in this step is the dihydropteroate synthase (DHPS). Dapsone competitively inhibits this consideration and ultimately results in the decreased production of tetrahydrofolate, an essential component of nucleic acid biosynthesis in Mycobacterium leprae. Thus, Dapsone acts against bacteria and protozoa by inhibiting the synthesis of dihydrofolic acid through competition with para-amino benzoate for the active site of dihydropteroate synthase.
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