Cyclopentolate is a muscarinic antagonist. It kind of anticholinergic agent, whose activity
blocks the muscarinic acetylcholine receptor. It is used before eye examinations like
refraction exams as an eye drop. It is used during pediatric eye examinations to dilate the
eye and prevent the eye from focusing/accommodating.
Cyclopentolate can also reverse muscarinic and central nervous system effects of indirect
cholinomimetic administration. Cyclopentolate temporarily widens the pupil of the eye and
relaxes the muscles of the eye.
Cyclopentolate is sold under the brand names Cyclogyl, Cylate, Mydrilate, and Pentair
Cyclopentolate was synthesized in 1952. It was synthesized as a chemical analog of
atropine. Cyclopentolate is one of several derivatives tested for pharmacological action in a
search for new and better antispasmodic agents.
Dosage and forms
Cyclopentolate is available as a solution to instill in the eye. When you go for the
examinations, the trained staff or the doctor will administer the medicine. It takes between 30
minutes to an hour for the drops to take effect and will keep the eye dilated for 24 hours.
Individuals with dark eye colors need higher doses for dilation.
When administered to a child, they must be watched closely for at least 30 minutes after
instillation and should not be fed for about 4 hours after installation in infants.
The cost of Cyclopentolate
In the USA, the consumers have to pay an average retail price of $19.32 for an eye dropper
containing 2ml of 1% solution. However, this medicine is significantly cheaper in the
developing world. In India, a 5ml supply of these drops costs only USD 0.70, or 70 cents.
How does Cyclopentolate Work?
Cyclopentolate anti-muscarinic actions block the receptors in the muscles of the eye.
Because these muscles are involved in controlling the pupil size and the shape of the lens,
blocking the reception dilates them. Cyclopentolate relaxes the sphincter of the iris and the
ciliary muscles. Topically application to the eyes causes a rapid, intense effect that is
maximal in 15 to 60 minutes.
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