Drug Name: Colesevelam Hydrochloride Chemical formulation: C31H67Cl3N4O Active ingredient: Colesevelam and Hydrochloride Common/generic brand name: Colesevelam Hydrochloride Approved by FDA or not: FDA approved Commonly marketed in: USA, Russia, India and CIS countries Density: Colesevelam hydrochloride comes as tablets with a strength of 625 mg. The typical adult dose is 6 tablets given once a day or 3 tablets taken twice a day. This medicine should be used with a supper and a glass of water. Oral Suspension of Colesevelam hydrochloride is also available. One 3.75 gram package, taken once every day, or one 1.875 gram packet, taken twice daily, is the help boost dose.

This drug, coupled with a healthy lifestyle, is used to decrease cholesterol in persons who have high blood cholesterol levels. Lowering cholesterol lowers the risk of heart disease and strokes, as well as helping to avoid heart attacks and strokes. Colesevelam is also used to treat high blood sugar in persons with type 2 diabetes when combined with a healthy diet and exercise. High blood glucose control can help avoid kidney disease, blindness, nerve impingement, traumatic amputation, and sexual function issues. Diabetic control can also reduce your chances of having a stroke or heart attack. Colesevelam belongs to the bile acid-binding resins class of medicines. Bile acid is a natural chemical produced by the liver from cholesterol. Bile acid is removed from the body by this drug. This allows the liver to produce more bile acid by utilizing cholesterol, lowering blood cholesterol levels. Colesevelam's mechanism of action in decreasing blood sugar is unknown.

Colesevelam Hydrochloride is available in tablet form.

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Colesevelam hydrochloride works in a variety of ways. This lipid-lowering polymer binds bile acids in the intestine, preventing their reuptake in the therapy of Primary Hyperlipidemia. The hepatic enzyme cholesterol 7--hydroxylase promotes cholesterol conversion into bile acids when the bile acid pool is reduced. This has the cumulative effect of increasing the need for cholesterol in liver cells. This has two effects: first, it boosts the expression and function of the cholesterol synthesis enzyme HMG-CoA reductase, and second, it boosts the number of hepatic LDL receptors. Increased clearance of LDL-C from the blood is one of the general compensatory effects. Eventually, the serum LDL-C levels in the blood are reduced. The use of this drug, on the other hand, may enhance or sustain Serum TG levels. Its method of action in the treatment of Type 2 Diabetes Mellitus is unknown, although it improves glycemic control.

Constipation and stomach distress are possible side effects. If any of these adverse effects continue or intensify, contact the doctor or pharmacist right away. To avoid constipation, eat lots of fibre, drink enough of water, and exercise. You could also need to take a laxative.

If you have any of the following unlikely but dangerous adverse effects like stomach cramps, abdomen pain, difficulty swallowing, or abnormal blood loss, contact the doctor straight once. Low blood sugar is not frequently a side effect of this drug (hypoglycemia). Low blood sugar can occur if this medication is administered with other diabetic drugs, if you don't eat enough calories, or if you exercise excessively. Sudden perspiration, shaking, a racing heart, restlessness, blurred vision, vertigo, or tingling palms are all signs of low blood sugar. Carrying glucose pills or gel to address low blood sugar is a smart habit.

This medicine seldom causes a severe allergic reaction. Nevertheless, if anyone detects any symptoms of a major allergic response, such as redness, itching/swelling, extreme dizziness, or problems breathing, seek medical help right once.

If you have diabetic ketoacidosis, very high triglycerides, a history of intestinal obstruction, or a past of pancreatitis caused by high triglycerides, you should not use colesevelam. Colesevelam should not be used by girls who have not yet started menstruating. Colesevelam should not be given to anyone under the age of ten.

No evidence of fetal damage has been found in animal investigations. Pregnancy has been reported infrequently in the postmarketing era, and a causative link to congenital abnormalities has yet to be demonstrated. In human pregnancy, there are no regulated data. There is no data regarding the effects of breastfeeding.

Colesevelam will not work as well if you eat foods heavy in fat or cholesterol.

Reduce your cholesterol and fat intake by eating a low-fat, low-cholesterol diet. Make sure to follow your doctor's or dietitian's exercise and dietary advice.

If somebody has taken an overdose of this medication and is experiencing dangerous symptoms like problems breathing or collapses, they should get medical help right away. Never exceed the dosage that the doctor has suggested for the person.

Heating, air, or light should not be allowed to come into direct contact with the medicine, since this may cause it to be damaged. The medication must be kept in a secure location out of reach of youngsters.