Caffeine is a chemical, which naturally occurs in coffee, tea, and is commonly used in cola,
guarana, mate, and other products. Caffeine is mainly used to improve mental alertness, but
it has several other applications. Caffeine is used by mouth in foods or rectally in
combination with painkillers like aspirin and acetaminophen. It is used in combination with
ergotamine in treating migraine headaches. Caffeine is also used with painkillers to relieve
simple headaches and treating headaches post epidural anesthesia. In some regions, it is
also used in the treatment of asthma, gallbladder disease, attention deficit-hyperactivity
disorder and many other conditions, however, these are yet to be scientifically studied and
Caffeine is sold in many products under several brands names across the world. In foods,
caffeine is used as an ingredient in soft, energy drinks, and other beverages.
Mr. Robiquet, first discovered Caffeine, in coffee in 1821. In 1895, Hermann Emil Fischer
was the first to synthesize caffeine from its chemical components and by 1897 had derived
the structural formula of the compound. Fischer was awarded the Nobel Prize in 1902.
Dosage and administration
In the normal course of the day, One cup of coffee contains 95-200 mg of caffeine. A 8-
ounces of black tea contains 40-120 mg and green tea contains 15-60 mg of caffeine.
Carbonated drinks contain 20-80 mg of caffeine for every 12-ounce serving and Sports or
energy drinks have 48-300 mg of caffeine.
For relief from headache, a dose 100-250 mg caffeine has found effective. Caffeine is also
prescribed in combination with aspirin, acetaminophen, ergotamine, and sumatriptan. For
relief from headache resulting from epidural anesthesia, the recommended dose is 300 mg.
For improving mental alertness, the recommended dose is 100-600 mg, taken daily. In the
treatment of Asthma, the dosage is 9 mg/kg and for improving athletic performance, the are
recommended to take 2-10 mg/kg. In prevention of gallstone disease, the recommended
dose is 400 mg or more, taken daily. For improving memory, the dose is 65-200 and for
obesity, Ephedrine/caffeine combination are recommended at a 20 mg/200 mg dose, taken
three times daily. For reducing pain, the recommended dose is 50-130 mg is used with pain
relievers including acetaminophen, or ibuprofen.
The cost of Caffeine
Most of the Caffeine consumed, is done during the course of the regular diet or caffeine rich
diet. However, the industrial Caffeine Anhydrous Powder, food and ingredient costs 137
pounds for 5kgs of the ingredient in the international market. In India, the consumers have to
pay, between USd15 and USD 20, for 1kg of the 99% Purity Powder.
How does Caffeine work?
Caffeine stimulates the central nervous system (CNS), heart, muscles in addition to
controlling the centers that control blood pressure. Caffeine raises blood pressure, but long
term users may not find it as effective as new users. Caffeine action also give it the
properties of a “water pill” which can increase the flow of urine. Excessive drinking of
caffeine can cause dehydration.
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