Clindamycin is an antibiotic used for the treatment of a number of bacterial infections,
including bone, joint, and pelvic inflammatory disease, many infections affecting the ear, nose, and throat region, and endocarditis. It can also be used to treat acne, dental infections, skin,
and soft tissue, and peritonitis. Patients who are hypersensitive to penicillins are also given
Clindamycin in the treatment of infections caused by susceptible aerobic bacteria. The topical
application of clindamycin phosphate is also to manage mild to moderate acne and some
cases of methicillin-resistant Staphylococcus aureus.
Clindamycin is marketed as Cleocin HCl, Clindacin, Dalacin, Evoclin, and Lincocin amongst
In 1966 Clindamycin was first extracted from lincomycin, which naturally occurs in a plant
found in Alaska. It is a generic medication and on the World Health Organization's List of
Forms and Dosage
Clindamycin forms administered orally include capsules and oral suspensions. Clindamycin
is a vaginal cream and vaginal ovules are used for the treatment of bacterial vaginosis. It is also
sold for topical administration in gel form, as a lotion, and in a foam delivery system and a
solution in ethanol and is used primarily as a prescription acne treatment. Common side
effects of using Clindamycin include nausea, diarrhea, rash, and pain at the site of
injection. For long term treatment of acne, the combined use of topical clindamycin and
benzoyl peroxide works just like salicylic acid plus benzoyl peroxide.
The common usual dose of Clindamycin is from 150 and 450mg every six-eight hours,
depending on the severity of the infection. Sometimes, Doctor can also prescribe
Clindamycin 600mg Capsules, the usual dose of which is one capsule every 8 hours.
The cost of Clindamycin
The wholesale cost in the developing world is US$0.06 to US$0.12 per pill whereas the same
medicine in the United States it costs about $2.70 per dose and the average price consumers
pay for 30 Capsules of 300mg each of the generic brands is $95.99.
How does Clindamycin work?
Clindamycin has a primarily bacteriostatic effect in that it works by slowing or stopping the
growth of bacteria. Just like antibiotics, Clindamycin works by inhibiting bacterial protein
synthesis thereby inhibiting bacterial growth. It also has a bacteriostatic effect in that it stops
bacteria from reproducing but can’t kill them. Clindamycin’s actions work by binding to the
50s ribosomal subunit of bacteria thus disrupting protein synthesis in the process by
interfering with the transpeptidation reaction, which thereby inhibits early chain elongation.
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