Clarithromycin is a macrolide broad-spectrum antibiotic that belongs to the class of medication macrolide antibiotics. This medication is used to treat bacterial infections that cause bronchitis, pneumonia, infections of the skin, throat, sinuses and ears.
Clarithromycin is also used to treat and prevent infection of the lung caused by Mycobacterium avium. This medication can also be used in combination with other anti-ulcer medication to treat certain types of stomach ulcers.
Clarithromycin manufacturers market this drug under the Brand name of Biaxin. Clarithromycin is advised as a prescription product, generic prescription product as well as mixture product.
Clarithromycin comes in a dosage form of Tablet, an extended-release tablet, and granules for suspension (liquid) which are taken by mouth. Tablet is available in dosage strengths of 250 mg and 500 mg, while oral suspension is available in 125 mg /5 mL and 250 mg/5 mL dosage strength.
The tablet and liquid are usually taken with or without food twice or thrice daily for a period of 1 to 2 weeks, and the extended-release tablet is taken with food once daily for 7 to 14 days and should be taken around the same time daily.
Clarithromycin Tablet and Solution are recommended to be stored at 20° C to 25° C (68° F to 77° F), in well-closed containers. Excursions permitted to 15° C to 30° C (59° F to 86° F).
Wholesale Price of Clarithromycin
The wholesale price for 50 units of 250 mg clarithromycin oral tablet is approximately $ 167.74 with per unit cost comes at $ 3.35
The per-unit cost of 500 mg clarithromycin oral tablet is approximately $ 2.82, which is available for a cost of $ 84.51 for 50 tablets whereas for a set of 60 tablets the price range is in between $ 7.50 - $ 159.53 and the per-unit cost is available at as low as $ 0.12
The cost for 500 mg clarithromycin oral tablet, the extended-release is around $ 67 for a supply of 14 tablets.
The cost for clarithromycin oral granules for suspension 125 mg /5 mL is around $ 42 for a supply of 50 milliliters, with the per-unit cost at $ 0.85
The cost for clarithromycin oral granules for suspension 250 mg /5 mL is around $ 73 for a supply of 50 milliliters, with the per-unit cost at $ 1.45
Clarithromycin - Mechanism of Action
Clarithromycin is a macrolide antibiotic and it exhibits its action by stopping the growth of bacteria. Clarithromycin is well absorbed and is stable in an acidic environment and gets metabolized to 14-OH clarithromycin which is active and works synergistically like its parent compound, which then penetrates the bacteria cell wall and reversibly binds to 50S ribosomal subunit of susceptible bacteria blocking translocation of aminoacyl transfer-RNA and polypeptide synthesis, which ultimately results in stopping the growth of bacteria.
Clarithromycin is bacteriostatic but it also acts as bactericidal depending on the organism and concentration of the drug.
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