Chlorpromazine
Chlorpromazine is an antipsychotic medication used to treat psychotic disorders, most
commonly schizophrenia or manic-depression in adults. Other conditions which are treated
using Chlorpromazine are Bipolar and Attention deficit hyperactivity syndrome in children. It
is also used for get relief from or in the treatement of nausea and vomiting, anxiety before
surgery, chronic hiccups, acute intermittent porphyria, and symptoms of tetanus. It acts at all
levels of the central nervous system-both at subcortical levels and on multiple organ systems.
In children aged between 1 and 12, it is used to treat severe combative or explosive behavior
problems or with excessive motor activity.
Chlorpromazine real advantage is that it is a low-potency typical antipsychotic and was given
to patients of both acute and chronic psychoses, which included schizophrenia, and the manic
phase of bipolar disorder, even in cases of amphetamine-induced psychosis. Low-potency
antipsychotics have low impact the brain performance in its side effects, but causes dry
mouth, sedation, and constipation.
Chlorpromazine is marketed under the trade names Thorazine and Largactil among others.
Paul Charpentier at Rhône-Poulenc, a French pharma company, first synthesized
Chlorpromazine in 1951. While Chlorpromazine had been in development since 1950 and
was widely touted to be the first antipsychotic, after it release it went on to become very
popular earning it accolade as one of the great advances in psychiatry. For it efficacy, It is
also on the World Health Organization's List of Essential Medicines.
Forms and Dosage
It can be given by mouth, by injection into a muscle, or into a vein.it is also sold as tablets in
the strengths of 10mg, 25mg, 50mg, 100mg and 200mg and the injectable solution has
25mg/ml. For psychotic disorders, the dosage is between 3-75 mg per day, for nausea and
vomiting from 10-25 gm per day, for pre-operative apprehension and hiccups from 25-50mg.,
What is the price of Chlorpromazine?
The price of Chlorpromazine varies between $25-$50 for a month’s dose of generic brand in
the USA, whereas the same supply cost 37.50 pounds in the UK. In India, the price varies
from USD1 to USD10 for a month’s supply.
How does Chlorpromazine work?
Chlorpromazine works by blocking a range of different receptors of the brain, in particular,
the dopamine receptors. Dopamine is a natural compound in the brain, that acts as a
neurotransmitter means that it helps transmitting messages between brain cells. By regulating
the dopamine, Chlorpromazine can regulate mood and behavior anamolies.
Particularly in Schizophrenia, which is caused by overactivity of dopamine, it blocks the
receptors that dopamine acts on resulting in decreased overactivity of dopamine resulting in
controlling psychotic illnesses.
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