Chlorphenamine:
Chlorphenamine, also known as chlorpheniramine, is a medication used in the treatment of allergic conditions, most commonly allergic rhinitis (hay fever). It was first patented in 1948, with chlorphenamine manufacturers and chlorphenamine suppliers listing it for both commercial sale and wholesale in 1949. Where it has since been sold under various brand names including Aller-Chlor, Chlo-Amine, Chlor-Trimeton, Polaramine, Allerlief, Ridramin, Pediatan, AllergyUni-Cortom, Wal-finate, and Teldrin among many others. This diversity in trade names and price points can be attributed, in large part, to the expiration of chlorphenamine’s pharmaceutical products patent, allowing for generics to be produced. Rendering it cost-effective and subsequently attractive for manufacturers, distributors, and suppliers to produce and list on the global marketplace. Currently, it has become ubiquitous with antihistamine drugs used to treat allergies, often being produced by chlorphenamine manufacturers and sold by chlorphenamine suppliers as a combination medication, conferring additional benefits.
Method of action of chlorphenamine:
Chlorphenamine is designated as a first-generation H1 antihistamine, indicating its central effect and conferred sedative property. This is enabled by its inverse agonistic binding to the H1 receptor compared to histamine, with allergic reactions predominantly being histamine driven. This is caused by histamine release post-cell-degranulation, induced through allergen interaction and cross-linkage with IgE antibodies situated on mast cells and basophils. Therefore, as histamine acting on the H1 receptor brings about allergy associated symptoms such as pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction, while also increasing vascular permeability and potentiates pain. Competitive antagonistic binding of chlorphenamine to this H1 receptor prevents histamine from binding, blocking its subsequent downstream effects. This thus results in temporary alleviation of histamine related symptoms including sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
Form and dosage of chlorphenamine:
The form in which chlorphenamine is listed for sale on the global marketplace is dependent on the specific company, with particular manufacturers and distributors having preferences. However, common forms typically consist of tablets, film-coated tablets, oral solutions, syrup, capsules, and various effervescent delivery methods. Chlorphenamine is not a prescription medication and thus is readily available over the counter for purchase, usually being taken once a day before bed due to its sedative effects. It can, however, be taken throughout the day when needed, up to a recommended maximum of 24 mg in 24 hours, with dosages decreased for those under the age of 12.
Chlorphenamine on Pipelinepharma:
Chlorphenamine is available for wholesale B2B order through our online Pipelinepharma.com marketplace. A current search, at the time of writing, displays over 80 trusted global listings from suppliers situated in countries including the European Union, Turkey, India, and Kosovo. These manufacturers, distributors, and wholesalers are verified by the Pipelinepharma team according to strict quality control, expediting sourcing and increasing both buyer and seller ease.
Price of chlorphenamine and how to buy:
Although the price of chlorphenamine remains negotiable and confidential between both B2B parties, manufacturers and suppliers may choose to list a desired cost for their product online. This is done to facilitate a quick and effortless trade, with the suggested price being displayed alongside the online Pipelinepharma marketplace listing. Thereby the buyer simply needs to click on ‘Accept’ to agree with the set price, ‘Negotiate’ to consult, or ‘Get offer’ to inquire if no such desired price is listed.