Chloroquine Phosphate Manufacturer
Chloroquine Phosphate is sold under the brand names Aralen, Chloroquine FNA, Dawaquin and Lariago among many others, available in the strength 250mg. This pharmaceutical medicine is classified as 4-aminoquinoline which works against the asexual form of malarial parasite and is available in the salts of phosphate, sulfate, and hydrochloride. It is mostly administered through oral routes in the form of tablets and is metabolized by the liver with elimination half-life 1-2 months. It is excreted mostly in urine , 50% or less as an unchanged drug and its elimination can be increased by acidification of urine. Its legal status around the globe is of ‘’ Prescription Only Medication’’. This drug is indicated for the treatment and prevention of malaria caused by certain malarial strains that are Plasmodium vivax, P. ovale, P. malariae but is not recommended in the malaria caused by Plasmodium falciparum as this strain is resistant to it. Other indications include amebiasis occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. It was also used in the treatment of COVID-19 initially but later in summer 2020 these studies were halted and is not recommended for this purpose nowadays. Common side effects are muscle problems, loss of appetite, diarrhea, and skin rash while serious side effects include vision problems, muscle damage, seizures, and anemia. FDA has not formally assigned any category for its use among pregnant women due to its safety profile hence it can not be used unless necessary. It is excreted into human breast milk but in small amounts, so decisions regarding its continuation should be made keeping mother’s and baby’s health in mind.
This pharmaceutical medicine is known to have drug interactions with Ampicillin, Antacids, Cimetidine, Cyclosporine and Mefloquine. It is contraindicated in conditions like hypoglycemia, G6PD deficiency, hypomagnesemia, hypokalemia, low levels of white blood cells and alcoholism. If you are suffering with any of the mentioned conditions, do inform your physician to avoid any kind of harmful clinical condition. It is accumulated in the body and can cause blurred vision and blindness due to its retinal toxicity effect so patients with long term use of the drug should visit an ophthalmologist regularly. The very first synthesis of Chloroquine was made and patented by IG Farben in 1937 and in 1949 its proper manufacturing process was introduced and allowed for its widespread use. It was exclusively introduced into clinical practices in 1947 for the prophylactic treatment of malaria. Overdose of this pharmaceutical drug in its any salt form has 20% chances of death as it is rapidly absorbed from the stomach and onset of action is within one hour with the symptom’s sleepiness, changes in vision, seizures, stopping of breathing and heart problems including hypotension and ventricular fibrillation. The usual dose for treatment is 10mg/kg while toxic dose begins with 20mg/kg and lethal dose is evidenced to be 30mg/kg of the total body weight.
How does Chloroquine Phosphate work?
It works by inhibiting the formation of hemozoin from the heme which is released by digestion of hemoglobin . This free heme lyses membranes and leads to death of parasites .
The cost of Chloroquine Phosphate
The price of a 250 mg Chloroquine Phosphate oral tablet is approximately 400 dollars. For a supply of 50 tablets and around 8.00 dollars per tablet. Price may vary among dealers.
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