Cefoxitin is a second-generation cephamycin antibiotic. Cefoxitin is used to treat Aspiration
Pneumonia, Cesarean Section, Gonococcal Infection – Uncomplicated, Intraabdominal
Infection, Joint Infection, Osteomyelitis, Pelvic Inflammatory Disease, Peritonitis,
Pneumonia, Septicemia, Bacterial Infection, Urinary Tract Infection, Skin and Structure
Infection, Surgical Prophylaxis, Tuberculosis - Urinary Tract, Streptococcemia, Infection -
Bacterial/Fungal/Protozoal/Viral and Endometritis.
It is also given before surgery to prevent the development of surgical wound infections and in
third and fourth-degree perineal injuries in women after giving vaginal birth. Cefoxitin
decreases the infection rate at two and six weeks.
Bioniche Pharma, LLC amongst others, sells Cefoxitin under the brand name Mefoxin.
Merck Inc. developed Cefoxitin from Cephamycin C in the year following its discovery in
1972, when it was synthesized to create a broader spectrum antibiotic.
Dosage Forms & Strengths
Cefoxitin is available as tablets and injections. The injections are sold in three major IV
doses of 1g, 2g, and 10g. In adults, Cefoxitin is administered every six to eight hours in 1g or
In the treatment of Uncomplicated Infections, the usual recommended dose is 1 g,
administered through Intravenous injections every 6 to 8 hours and for Moderate-Severe
Infections, the dose is 1 g every 4 hours or 2 g every 6- 8 hours. The usual adult dose
recommended in the treatment of Gas Gangrene or Infections commonly requiring antibiotics
in a higher dosage is 2 g every 4 hours or 4 grams every 4 hours.
For Prophylaxis post-Surgery, preventing infection post-Colorectal, non-perforated
appendectomy or hysterectomy, and Ruptured viscus, the usual recommended adult dose is
1-2 g injected every 6 hours.
The price of Cefoxitin
In the USA, consumers have to pay around $430 for a supply of 10 powders for injection for
10 gm injection. In India, a supply of 1 gram of this powder in the ingredient form costs
How does Cefoxitin work?
Cefoxitin is from a family of medicines called the beta-lactam antibiotic. This type of antibiotic
binds to penicillin-binding proteins called transpeptidases. After binding to PBPs, its actions
prevent PBPs from forming the cross-linkages between the peptidoglycan layers in the
bacterial cell wall, interfering with cell wall synthesis. Cefoxitin is a bactericide that inhibits
bacterial cell wall synthesis.
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