Betamethasone dipropionate is classified as a super high potency corticosteroid used as an anti-inflammatory or immunosuppressive agent. Betamethasone dipropionate treats a wide range of skin conditions like eczema, dermatitis, allergies, and rashes. It’s actions reduce the swelling, itching, and redness caused by these conditions. Betamethasone dipropionate is prescribed in the treatment of cutaneous T-cell lymphoma, seborrheic dermatitis that causes allergic red and itchy skin called atopic dermatitis. Also prescribed to cure contact dermatitis, inflammation of the skin due to an allergy and contact with the offensive substance, granuloma Annulare, plaque psoriasis, psoriasis of itching of the anus, itching of the genital area, scalp, skin rash that becomes thick and discolored from rubbing it, skin inflammation and itching. It is commonly used in combination with other drugs such as Luxiq, Lotrisone, and Taclonex.
Betamethasone dipropionate is sold under the brand names Alphatrex, Beta-Val, and Diprolene amongst others.
Merck patented Betamethasone dipropionate in 1987 was, as an augmented cream/lotion, in the U.S. and Europe. But these patents have expired since then leading to a generic production of betamethasone dipropionate by several other local manufacturers in countries around the world.
Dosage, forms, and application:
Betamethasone dipropionate is available systemically (injectable and oral) and as Topical formulations with medium to very high potency. Its cream/lotion/ointment are available in 0.05%, 0.1%, concentrations whereas the gel has only the 0.05% variant. It’s foam form has a strength of 0.12% and the spray has 0.05% of medicine per gram.
In the treatment of Plaque Psoriasis, indicated for treating mild-to-moderate plaque psoriasis in adults, the patient has to apply it directly to the affected area once every 12 hours. In the treatment of Steroid-Responsive Dermatoses, the patient has to apply the ointment, cream, lotion, or gel once every 12 hours.
The price of Betamethasone dipropionate
In the USA, consumers have to pay an average retail price of $82.43 for a generic tube of cream of 45g of 0.05% concentration of this medicine. The price of this medicine is significantly cheaper in India with prices as low as USD5 for the same supply.
How does Betamethasone dipropionate work?
Betamethasone is corticosteroids. Broadly speaking, its actions activate natural substances in the skin to reduce swelling, redness, and itching. It achieves this by binding to specific intracellular glucocorticoid receptors. It then subsequently binds to DNA modifying the gene expression. The resulting synthesis induces anti-inflammatory proteins while prohibiting the synthesis of other inflammatory mediators..
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