Betahistine is an anti-vertigo medication. It is prescribed in the treatment of balance disorders or to
alleviate vertigo symptoms, those associated with Ménière's disease. Symptoms of Ménière's disease
include dizziness expressed as vertigo, ringing in the ears called tinnitus, loss of hearing, feeling sick
like nausea. Patients with Ménière’s disease develop excess fluid buildup in the inner ear structures.
This Excess fluid interferes with the nerve signals sent by inner ear structures to the brain helping a
person balance, movement, and position.
It is also under clinical trials for the treatment of Attention Deficit Hyperactivity Disorder. Its actions
can dilate the blood vessels in the inner ear, which relieves pressure from excess fluid, and act on the
smooth muscle. It is also hypothesized that it can increase the level of serotonin in the brainstem, thus
inhibiting the activity of vestibular nuclei.
Betahistine is sold under the brand name Serc among others.
Betahistine was first registered in Europe in 1970 for the treatment of Ménière's disease. But,
Betahistine did not get approved for marketing in the United States in the past few decades.
Forms and dosage
Betahistine comes in a tablet as well as an oral solution and is taken orally. It is rapidly and
completely absorbed in the body. Betahistine is sold as 8mg or 16mg tablets. It is for adults use only.
The patient normally takes tablets 3 times a day, with 6 to 8 hours between doses. The common side
effects include headache, feeling sick, or indigestion. It is best taken with or after food, as this way it is
least likely to upset stomach.
The cost of Betahistine
In the USA and Canada, The lowest price consumers pay for Betahistine 16 mg is $0.37 per pill or
unit for 90 pills. Whereas the branded version sells for USD49 in the UK for a 120 pill supply of 8mg.
The same supply costs USD58 for a supply for 90 pills. The price for the same is USD81 in Canada
and higher still in European countries.
How does Betahistine work?
Betahistine is a strong antagonist of the histamine H3 receptor, at the same time a weak agonist of
the histamine H1 receptor. Betahistine primarily has two mechanisms of action; it is a weak agonist on
the H1 receptors located on blood vessels in the inner ear, which gives rise to local vasodilation and
increased permeability. This eventually helps in reversing the underlying problem of endolymphatic
hydrops. Critically, it also has powerful antagonistic effects at H3 receptors, so it can aid in increasing
the levels of neurotransmitters histamine, acetylcholine, norepinephrine, serotonin, and GABA
released from the nerve endings of patients. The increase in histamine release from histaminergic
nerve endings stimulates the receptors resulting in potent vasodilatory affects the inner ear.
Finding Betahistine Manufacturers and Betahistine Suppliers
One of the fastest and easiest ways to find Betahistine manufacturers and Betahistine suppliers is to
make use of Pipelinepharma's global B2B online marketplace for medicines and other
Usually, finding trusted manufacturers and supplies of specific drugs like Betahistine can be a time-
consuming challenge, but with Pipelinepharma's simple search engine and network of proven
partners, the whole process becomes a lot easier.
All you need to do to get started is make use of our integrated search engine and start looking for
suppliers or manufacturers of Betahistine to work with. You can fine-tune your search results using
various filters too, letting you search for Betahistine from specific countries, for example.