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Vardenafil hydrochloride manufacturers

4 products found

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4 products found

vardenafil hydrochloride

Tablets, orally disintegrating (ODT) 10 mg - 8'S

Dossier type
EU CTD
Country of origin
European Union
Dossier status
Ready
GMP approvals
EU GMP
Registered in
Ireland, Italy, United Kingdom, Germany

Manufacturer #337

A pharmaceutical manufacturer based in the EU that has been active in 90+ countries selling its products in the EU, Africa, North America, Middle East, and Asia for 30+ years. Key production lines are Rx and OTC. Main therapeutic areas include diabetes, CNS, and dermatology. The company's production lines are GMP-compliant. The company possesses branches in the Middle East and Asia.

Manufacturer usually replies in 5 days

vardenafil hydrochloride

Tablets 5mg, 10mg, 20mg

Dossier type
EU CTD
Country of origin
Switzerland
Dossier status
Ready
GMP approvals
EU GMP
Unavailable markets
Germany, United Kingdom, Poland, Vietnam

Manufacturer #269

A pharmaceutical manufacturer based in the EU that is active in 100+ countries selling its products in Europe, North America, Africa, the Middle East, and Asia for 40+ years. Main therapeutic areas include CNS, cardiovascular medication, and anti-infectives. The company's production lines are EU GMP-compliant. Key production lines are Rx and OTC. The company owns 20+ branches in Europe, Africa, and Asia.

Manufacturer usually replies in 5 days

vardenafil hydrochloride

Tablets 2.5mg, 5mg, 10mg, 20mg

Dossier type
US CTD
Country of origin
Switzerland
Dossier status
Ready
GMP approvals
FDA
Unavailable markets
Poland, United Kingdom, Germany, Vietnam

Manufacturer #269

A pharmaceutical manufacturer based in the EU that is active in 100+ countries selling its products in Europe, North America, Africa, the Middle East, and Asia for 40+ years. Main therapeutic areas include CNS, cardiovascular medication, and anti-infectives. The company's production lines are EU GMP-compliant. Key production lines are Rx and OTC. The company owns 20+ branches in Europe, Africa, and Asia.

Manufacturer usually replies in 5 days

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VARDENAFIL HYDROCHLORIDE

Vardenafil Hydrochloride is an oral therapy. It is used to treat erectile dysfunction. It works by selectively inhibiting cGMP-specific PDE5. In a hemodynamic process, Penile erection is initiated by the relaxing the smooth muscles in the corpus cavernosum and its associated arterioles. Nitric oxide gets released during sexual stimulation from nerve endings and endothelial cells in the corpus cavernosum which activates the enzyme guanylate cyclase increasing the synthesis of cGMP in the smooth muscle cells of the corpus cavernosum. cGMP eventually triggers smooth muscle relaxation, allowing increased blood flow into the penis, resulting in erection. Both the rate of synthesis and degradation via PDEs regulate tissue concentration of cGMP. The most abundant PDE in the human corpus cavernosum is the cGMP specific PDE5. So inhibiting PDE5 enhances erectile function by increasing the amount of cGMP. It is similar to other PDE5 inhibitors and functions similar to sildenafil citrate and tadalafil. The difference between in structure with sildenafil and vardenafil is in its relatively short effective time. Vardenafil may also be used to treat premature ejaculation, where it can increase the time from penetration to ejaculation. Vardenafil Hydrochloride is sold under the brand names like Vardenafilo and Vardenafilum among others. Bayer Pharmaceuticals, GlaxoSmithKline, and Schering-Plough co-marketed it under the trade name Levitra. As of 2005, Bayer had earned rights in more markets outside the U.S. In Italy, Bayer sells vardenafil as Levitra and GSK sells it as Vivanza. Levitra Soft, An orally disintegrating form, marketed as Staxyn, has been gaining approvals in countries such as the United States and Canada.

Forms & Dose:

It is available in round orange tablets in 2.5 mg, 5 mg, 10 mg, and 20 mg doses. Usually, the recommended initial dose is 10 mg, which is roughly same as 50 mg of sildenafil. The best time to take Vardenafil is 1 to 2 hours prior to sexual activity, but not more than once a day. For this reason, some of the countries like UK sells only some of the doses. In some cases, dosage could be increased to 20 mg, the highest permissible per day or decreased to 5 mg depending on a combination of efficacy and side effects.

The price of Vardenafil hydrochloride

In the USA, the consumers have to pay an average retail price of $455.47 for a supply of 10 tablets of 20mg dose. The same supply of a generic brand in India cost US$19.

How does Vardenafil Hydrochloride work?

Vardenafil Hydrochloride inhibits the cGMP PDE5 responsible for degradation of cGMP in the corpus cavernosum located around the penis. In a hemodynamic process, Penile erection is initiated by the relaxing the smooth muscles in the corpus cavernosum and its associated arterioles. Nitric oxide gets released during sexual stimulation from nerve endings and endothelial cells in the corpus cavernosum which activates the enzyme guanylate cyclase increasing the synthesis of cGMP in the smooth muscle cells of the corpus cavernosum.

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