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triprolidine + pseudoephedrine

Syrup 1.25 mg+30 mg

Dossier type
CTD
Dossier status
Ready to file
Country of origin
India
GMP approvals
WHO
Manufacturer #19472
This company is a manufacturer and exporter of pharmaceutical products with over two decades of experience. They operate across three manufacturing facilities in India, specializing in a wide range of dosage forms including tablets, capsules, liquids, injectables, topicals, and nasal sprays. Their product portfolio encompasses generic, branded, nutraceutical, over-the-counter (OTC), and herbal medicines. Key therapy areas are not explicitly mentioned. They adhere to stringent quality standards with ISO 9001:2008 certification. The company exports its products to numerous regions globally, including the EU, North America, Africa, and the Middle East.

Manufacturer usually replies in 19 days

dextromethorphan + phenylephrine + triprolidine + menthol

Syrup 10 mg + 5 mg + 1.25 mg + 1.5 mg - 100 ml

Dossier type
CTD
Dossier status
Ready to file
Country of origin
India
GMP approvals
PICS
Manufacturer #2693
This global pharmaceutical company specializes in a wide range of dosage forms, including capsules, creams, injections, oral solids, and transdermal patches. They are renowned as the world's largest manufacturer of suppositories and pessaries. Their product portfolio spans several key therapy areas such as pain management, women's health, and dermatology. They hold GMP certifications and have patents on numerous products. The company operates state-of-the-art manufacturing facilities in multiple regions including the EU and North America, ensuring a global reach for their pharmaceutical offerings.

Manufacturer usually replies in 23 days

triprolidine + phenylephrine + paracetamol

Oral suspension 0.625 mg + 5 mg + 125 mg

Dossier type
CTD
Dossier status
Ready to file
Country of origin
India
GMP approvals
WHO
Manufacturer #20275
The company is a well-established pharmaceutical manufacturer with a strong presence in both domestic and international markets. It operates state-of-the-art manufacturing facilities in South Asia, adhering to stringent regulatory standards such as USFDA, UKMHRA, and EU. The company’s extensive R&D center focuses on novel formulation development and preclinical and clinical studies. Internationally, the company exports to numerous countries, including operations across Russia, Africa, Kazakhstan, Myanmar, and Papua New Guinea. With a robust strategy for contract manufacturing, strategic alliances, and licensing, the company is committed to quality, innovation, and expanding its global footprint in the pharmaceutical industry.

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Triprolidine

Triprolidine is an antihistamine medication. It relieves symptoms of allergy, hay fever, and the common flu. These allergies have symptoms likes rashes, watery eyes, itchy eyes, nose, throat, skin, cough, runny nose, sneezing and other breathing illnesses such as sinusitis, bronchitis. Triprolidine works by blocking histamine during an allergic reaction. It also blocks acetylcholine that helps dry up some body fluids to relieve symptoms such as watery eyes and runny nose. Triprolidine is sold under the brand names Actidil, Myidil, Actifed amongst others.
Burroughs Wellcome Co patented it in 1948 and it came into medical use in 1953. However, that patent expired. Warner Lambert Co LLC got a patent to sell this medicine in 1998 and FDA granted its approval in 2001. Given its wide range of applications, it is manufactured and licensed by several companies around the world for various novel formulations designed to treat specific conditions.

Forms and dosage:

Triprolidine is available as an oral liquid in 0.5mg/mL and 0.625mg/mL options. In the treatment of Allergic Rhinitis, as Indicated for temporary relief of rhinorrhea, sneezing, itchy nose, throat, or eyes owing to fever or other upper respiratory allergies or allergic rhinitis, the recommended adult dose is 2.5 mg (5 mL) every 6 hours. To get relief from the symptoms of Allergic Conjunctivitis, the Usual Adult Dose is 2.5 mg taken orally every 6 hours not to exceed 10mg per day. In children, the Usual Pediatric Dose for Allergic Rhinitis in kids aged 4 months to less than 2 years is 0.310 to 0.313 mg, given orally every 6 hours not to exceed 1.25 mg per day. For kids aged 2 to 4 years old, the dose is 0.625 to 0.628 mg, for kids between 4 years and 6 years, it is 0.938 to 0.939 mg. For kids between 6-12 years old, the dose is 1.25 mg, taken orally every 6 hours and for kids older than 12 years the dose is 2.5 mg orally every 6 hours.

The cost of Triprolidine

In the USA, the consumers have to pay around $71 for a supply of 50 milliliters of triprolidine oral liquid (0.313 mg/mL). whereas the same supply would cost around a dollar in India per vial.

How does Triprolidine work?

Triprolidine has anticholinergic and sedative actions. Triprolidine binds to the histamine H1 receptor. This blocks the action of endogenous histamine. This blocking of histamine leads to temporary relief of the negative symptoms brought on by histamine in the first place.

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