Trimetazidine is used in the long term treatment and management of angina. Angina is chest pain
arising from the heart muscle when it falls short of enough oxygen for healthy functioning. The
patients get a feeling of indigestion, fullness, pressure, or tightness in the chest spreading to arms or
neck. In some countries, it is also used for treating tinnitus and dizziness. It works by improving the
myocardial glucose utilization through inhibition of fatty acid metabolism, also known as a fatty acid
Trimetazidine is a drug for angina pectoris sold under brand names called Vastarel.
Trimetazidine was developed and marketed by Laboratoires Servier (France). Trimetazidine is not
sold widely in the USA as it does not have FDA approval for sale in the United States.
Forms and Dose
Trimetazidine hydrochloride is sold as a modified, extended-release tablet. It is taken orally with
meals. This medicine is for adults only. The recommended dose is, modified extended-release tablets
of 20 mg to be taken three times a day or 35 mg. the treatment is reassessed after 3 months, if no
improvement is observed, the medication can be continued.
The cost Trimetazidine Hydrochloride
In the USA, the wholesale cost of the 50mg of this powder costs USD100, whereas the importing
price in different countries varies between USD 100 and USD 200 per kilo. In India, the 35 mg tablet
costs USD0.12 cents.
How does Trimetazidine Hydrochloride work?
Trimetazidine Hydrochloride improves myocardial glucose utilization through inhibition of long-chain 3-
ketoacyl CoA thiolase activity. This results in a reduction in fatty acid oxidation and stimulates glucose
oxidation. High fatty acid oxidation rates are detrimental in ischemia because of inhibition of glucose
oxidation leading to uncoupling of glycolysis and an increase in proton production. This has the
potential to accelerate sodium and calcium overload in the heart, which leads to an exacerbation of
ischemic injury and decreased cardiac efficiency during reperfusion.
Finding Trimetazidine Hydrochloride Manufacturers and Trimetazidine Hydrochloride
One of the fastest and easiest ways to find Trimetazidine Hydrochloride manufacturers and
Trimetazidine Hydrochloride suppliers is to make use of Pipelinepharma's global B2B online
marketplace for medicines and other pharmaceuticals.
Usually, finding trusted manufacturers and supplies of specific drugs like Trimetazidine Hydrochloride
can be a time-consuming challenge, but with Pipelinepharma's simple search engine and network of
proven partners, the whole process becomes a lot easier.
All you need to do to get started is make use of our integrated search engine and start looking for
suppliers or manufacturers of Trimetazidine Hydrochloride to work with. You can fine-tune your search
results using various filters too, letting you search for Trimetazidine Hydrochloride from specific
countries, for example.