Trihexyphenidyl hydrochloride is an active ingredient used in the manufacturing and formulation of antiparkinsonian medications. It is also commonly referred to by its other names of benzhexol and trihex, and is used in these antiparkinsonian drugs due to its clinical effect of reducing the frequency and duration of oculogyric crises. As well as that of dyskinetic movements and spastic contractions. It was first approved for commercialisation on the medical pharmaceutical products marketplace in 2003 by the FDA in the United States, with other approvals from various countries subsequently being granted. Currently, it is produced by many trihexyphenidyl hydrochloride manufacturers and trihexyphenidyl hydrochloride suppliers, being frequently found on the pharmaceutical products for sale list of distributors across the global marketplace, who have it readily available for wholesale order at a variety of cost and price points.
Mechanism of Trihexyphenidyl hydrochloride:
Trihexyphenidyl hydrochloride is a medication that has antiparkinsonian effects. This is due to it being a selective M1 muscarinic acetylcholine receptor antagonist, able to discriminate between the M1 (cortical or neuronal) and the peripheral muscarinic subtypes (cardiac and glandular). Trihexyphenidyl hydrochloride inhibits cholinergic activity in the central nervous system, whose abhorrent activation is largely responsible for symptoms of Parkinson's disease. Studies have also indicated that it increases the availability of dopamine, a brain chemical that is critical in the initiation and control of voluntary muscle movement.
Form and dosage of Trihexyphenidyl hydrochloride:
The final form and packaging of trihexyphenidyl hydrochloride are dependent on the manufacturers and suppliers, as well as the specific distributors and order. However, trihexyphenidyl hydrochloride typically comes in tablets or oral solution forms when listed for sale or wholesale. For the treatment of Parkinson's disease in adults, the recommended dose (if used in combination therapies) is approximately 2–6 mg daily in divided doses. For the treatment of Parkinsonism, it is 1 mg daily with an upwards adjustment of 2 mg every 3–5 days. Followed by a maintenance dose of 5–15 mg daily in 3–4 divided doses, to a maximum of 20 mg per day. All doses are lowered for the elderly due to a higher risk of toxicity and aggravating dementia. For further information please refer to the manufacturers’ literature or an accredited medical official.
Trihexyphenidyl hydrochloride on Pipelinepharma:
Currently, at the time of writing, we have found 6 verified trihexyphenidyl hydrochloride manufacturers and trihexyphenidyl hydrochloride suppliers from our online global list of B2B sellers. These manufacturers, suppliers, and distributors are located in countries including Ukraine, the United States, Mexico, India, and Jordan. Each company with a pharmaceutical products list visible on our online database has been individually verified by the Pipelinepharma team. This ensures seller reputability while reducing sourcing mileage and dead ends.
Price of Trihexyphenidyl hydrochloride and how to buy:
A cursory search online reveals an approximate price for wholesale trihexyphenidyl hydrochloride is USD 14.11 for 84 x 2 mg tablets. This is the price indicated for wholesale to the NHS in the United Kingdom, as such, it is given solely to serve as a generalisation of the current market values. As with all drugs and pharmaceutical products, the exact cost will be highly dependent on the individual purchase. Although prices on our online B2B marketplace are confidential, manufacturers may choose to list the desired price for their product to facilitate a quicker transaction. If so, this will be indicated alongside an ‘Accept’ and ‘Negotiate’ button, with a ‘Get offer’ button being displayed in the absence of a listed price.