Triamcinolone Hexacetonide

Triamcinolone Hexacetonide is used to treat and manage conditions like allergic disorders, arthritis, gout, blood diseases, breathing problems, certain cancers, eye diseases, intestinal disorders, and collagen and skin diseases. It is also used to treat Rheumatoid arthritis, Juvenile Idiopathic Arthritis, Osteoarthritis and post-traumatic arthritis, Synovitis, tendinitis, bursitis, and epicondylitis. Triamcinolone is a corticosteroid hormone called glucocorticoid. Triamcinolone Hexacetonide improves the body's immune response to these diseases and reduces symptoms such as swelling. Triamcinolone hexacetonide is sold under the brand name Aristospan amongst others. Smith And Nephew Associated Companies Limited filed the first known patent for Triamcinolone hexacetonide in 1980. Genzyme is one of the current assignees of the FDA license.

Dosage and administration

Triamcinolone hexacetonide is sold as Suspension for injection, it is Milky white suspension, and is easily suspendable. Every ml of the suspension for injection contains 20 mg triamcinolone hexacetonide and 9 mg of benzyl alcohol per ml and 455 mg sorbitol per ml. It is critical that the user is observed for Asepsis. Shake the vial to ensure suspension and sterilize the injection site using the lumbar puncture technique. In every treatment session, only two joints at the most are injected. As an Intraarticular injection, the recommended dose could be between 2-20 mg. the dose is set according to the size of the joint and the amount of articular fluid by each individual. Large joints like hip, knee, shoulder need a dose between 10-20 mg, medium-sized joints need a dose of 5-10 mg, and the smaller joints need a dose of 2-6 mg. it is long-acting, so the administration should not be more frequent than once every 3-4 week interval. The Periarticular injection formulation is given to adults and adolescents only. In the treatment of Bursitis or Epicondylitis, the usual recommended adult dose is 10-20 mg subject to the size of the bursa and the severity of the disease and in the treatment of Synovitis or Tendinitis; the recommended dose is 10-20 mg. the number of injections needed is decided based on the response from the patient.

The Price of Triamcinolone Hexacetonide

In the USA, the consumers have to Pay a retail Price of USD22.90 for a 1 milliliter of supply and cost USD45 for a supply for 5ml of this injection.

How does Triamcinolone Hexacetonide Work?

Glucocorticoids are naturally occurring but can also be made synthetically. These are adrenocortical steroids, which get absorbed from the gastrointestinal tract. Naturally, occurring glucocorticoids like hydrocortisone and cortisone with salt-retaining properties replace the adrenocortical deficiency. Glucocorticoid synthetic forms are used for anti- inflammatory effects.

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References

https://www.medicines.org.uk/emc/medicine/28913#gref https://www.webmd.com/drugs/2/drug-5590/triamcinolone-hexacetonide-injection/details https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/016466s046lbl.pdf https://www.sciencedirect.com/topics/medicine-and-dentistry/triamcinolone-hexacetonide