TRANYLCYPROMINE MANUFACTURERS

Tranylcypromine is an antidepressant, more specifically a monoamine oxidase inhibitor. This medication treats depression by restoring the balance of certain natural substances or neurotransmitters in the brain. It helps to improve your mood and feelings of well-being. A propylamine is generally formed from the cyclization of the side chain of amphetamine. Usually, monoamine oxidase inhibitor is effective in the treatment of: major depression, dysthymic disorder, and atypical depression. panic and phobic disorders Tranylcypromine is basically a kind of racemate that comprises equal amounts of (1R,2S)- and (1S,2R)-2- phenylcyclopropane -1- amine along with the chiral centers both located on the cyclopropane ring. This is actually an irreversible monoamine oxidase inhibitor that is used as an antidepressant. Tranylcypromine is a non-hydrazine monoamine oxidase inhibitor with a rapid onset of activity. MAO is an enzyme which functions to catalyze the oxidative deamination of a number of: amines, including serotonin, norepinephrine, epinephrine, and dopamine. There are two forms of MAO such as A and B which are found in the body. MAO-A is mainly found within cells located in the periphery. It catalyzes the breakdown of serotonin, norepinephrine, epinephrine, dopamine, and tyramine. MAO-B functions on norepinephrine, epinephrine, phenylethylamine, dopamine, and tyramine. It is localized extracellularly and is found predominantly in the brain. Although the mechanism of MAOIs is still unclear. It is thought that the functions in increasing free serotonin and norepinephrine concentrations by altering the concentrations of other amines in the CNS. It has been found that depression is caused by low levels of serotonin and/or norepinephrine and that increasing serotonergic and norepinephrinergic neurotransmission results in the relief of depressive symptoms. MAO-A inhibition is actually more relevant to antidepressant activity than MAO B inhibition. Very few MAO-B inhibitors have no antidepressant effects. In overdosage, some patients exhibit: insomnia, restlessness and anxiety, progressing in severe cases to agitation, mental confusion and incoherence. Hypotension, dizziness, weakness, and drowsiness, in extreme cases to extreme dizziness and shock. Very few patients are found to have hypertension with severe headaches and other symptoms.It is rare in reports that hypertension was accompanied by twitching or myoclonic fibrillation of skeletal muscles with hyperpyrexia. sometimes which progresses to generalized rigidity and coma.

HOW DOES TRANYLCYPROMINE WORK?

Tranylcypromine eccentrically and without any reverse inhibits monoamine oxidase.MAO, only within neurons appears to regulate the levels of monoamines released upon synaptic firing. Depression is basically associated with low levels of monoamines. The inhibition of MAO serves to ease depressive symptoms when it results in an increase in the concentrations of these amines within the CNS.

WHOLESALE PRICE OF TRANYLCYPROMINE

The lowest price for the common version of tranylcypromine oral tablet 10 mg is around $170 for a supply of 100 tablets. The price may vary and depends on the pharmacy you visit.

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