TIOTROPIUM

Tiotropium is a synthetic anticholinergic agent. It is prescribed as an inhalant for the treatment of acute bronchospasm due to chronic bronchitis or emphysema. It controls and prevents symptoms like wheezing, shortness of breath caused by chronic obstructive pulmonary disease-COPD. COPD includes bronchitis and emphysema. Tiotropium relaxes the muscles around the airways so that they open up and breathe more easily. Controlling symptoms of COPD and similar conditions can decrease time lost from work or school and improves the quality of life. It has been used regularly for best effects, for urgent breathing problems like wheezing and shortness of breath patients can use quick-relief inhalers like albuterol or salbutamol. Tiotropium is sold under the brand names Spiriva, HandiHaler, and Spiriva Respimat among others. Glaxo Group Limited patented it in 1989 and approved it for medical use in 2002. Tiotropium features on the WHO's List of Essential Medicines. However, due to its wide use, it is now made and marketed in several countries.

Dosage Forms and administration:

Tiotropium is available as a powder for oral inhalation in a Capsule to be used in a Handihaler with 18mcg of medicine in it. It is also sold as a Solution for inhalation in 1.25 mcg per actuation and 2.5 mcg per actuation. For Maintenance treatment of bronchospasm associated with COPD or reduction of COPD exacerbations, the recommended dose is 2 orally inhalations of 1 capsule of 18 mcg once a day via HandiHaler inhaler and If using the solution for inhalation the dose is 5 mcg, taken as 2 actuations inhaled orally once a day. For the long term, maintenance of asthma, the pediatric dose is for kids aged 6 years or older is 2.5 mcg, taken as 2 actuation, two 1.25 mcg actuation inhaled orally once a day. The Price of Tiotropium: In India, Tiotropium 18mcg Transcaps Capsules costs around USD2. A supply of 30 roto caps for handihaler cost around USD 2.2. this medicine is significantly more expensive in the developed world. In the USA, consumers have to pay USD108 for 5 inhalation capsules of 18 mcg strength.

HOW DOES IT WORK?

Tiotropium actions relax the muscles around the airways. This results in them opening up so that breathing becomes easy. Tiotropium is anticholinergics, that works by controlling symptoms of breathing problems. Tiotropium is a long-acting medication that has a strong affinity to the subtypes of muscarinic receptors M1 to M5. By Inhibiting the M3-receptor at the smooth muscle results, it relaxes the airways.

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