Thiamazole is a medication used to treat hyperthyroidism. It is also known as methimazole.
It is to treat Graves disease, toxic multinodular goiter, and thyrotoxic crisis. It is taken orally. This medication may take a few weeks’ full effects to occur.
Common side effects include :
itchiness, hair loss,
nausea, muscle pain,
Severe side effects may include:
low blood cell counts,
liver failure, and vasculitis.
Do not use it during the first trimester of pregnancy. You may use it in the second trimester or third trimester. It may also be used during breastfeeding. Those who developed significant side effects may also have problems with propylthiouracil. Thiamazole is a kind of thioamide and it functions by decreasing the production of thyroid hormones.
It was approved for medical use in the United States in 1950. The World Health Organization listed it among their Essential Medicines as the safest and most effective medicines needed in a health system. It is available as a generic medication everywhere in the USA. A monthly supply in the United States has a wholesale cost of about US $6.80 for this medicine. It is also available in Europe and Asia. It was ranked as the 244th most commonly prescribed medication in the United States in 2017, with more than one million prescriptions.
Thiamazole is a drug used to treat hyperthyroidism. This condition occurs when the thyroid gland begins to produce an excess of thyroid hormone. It is also known as Graves' disease. The drug also can be taken before thyroid surgery in order to lower thyroid hormone levels and minimize the effects of thyroid manipulation. Besides it also is used to treat hyperthyroidism in cats in the veterinary.
While taking thiamazole, it is important to monitor any symptoms of fever or sore throat. This symptom could indicate the development of agranulocytosis. An uncommon but severe side effect resulting from a drop in the white blood cell count. To be specific, neutropenia, a deficiency of neutrophils. To confirm the suspicion, a complete blood count (CBC) with differential is performed in necessity the drug is discontinued. Administration of recombinant human granulocyte colony-stimulating factor or the-CSF may increase recovery.
Other known side effects include:
skin rash, itching
abnormal hair loss
loss of taste
abnormal sensations such as tingling, prickling, burning, tightness, and pulling.
swelling, joint and muscle pain
decreased platelet count or thrombocytopenia,
aplasia cutis congenital or prenatal exposure,
thyroid gland enlargement or prenatal exposure,
choanal atresia or prenatal exposure during the first trimester of pregnancy.
How Does Thiamazole Work?
Thiamazole chiefly prevents thyroperoxidase. Which normally acts in thyroid hormone synthesis by oxidizing the anion iodide to iodine and hypoiodous acid. An enzyme-linked hypoiodate facilitating iodine's addition to tyrosine residues on the hormone precursor thyroglobulin. That is an essential step in the synthesis of triiodothyronine and thyroxine.
Again It does not prevent the action of the sodium-dependent iodide transporter located on follicular cells' basolateral membranes. Because the Inhibition of this step requires competitive inhibitors such as perchlorate and thiocyanate.
The Wholesale Price of Thiamazole
The lowest price for the common version of this pharmaceutical substance is around USD $24 for a supply of 100 tablets. The price may vary and depends on the pharmacy you visit.
Sourcing Thiamazole Manufacturers and Thiamazole Suppliers
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