Sotalol is a beta-blocker used to treat a life-threatening heart rhythm problem called ventricular arrhythmia. It also used to treat fast or irregular heartbeats (atrial fibrillation/flutter) in patients with severe symptoms such as weakness and shortness of breath.
Sotalol belongs to a class of medication called Antiarrhythmics.
This medication is advised as a prescription product as well as a generic prescription products.
Sotalol is marketed by manufacturers under the Brand name of Betapace, Sorine, Sotylize.
This drug is issued on prescription only. This medication is available in the form of Tablet, Oral Solution and Injectable Solution. Tablet and Oral Solution are taken by mouth while Injectable Solution is administered intravenously. Sotalol is available in dosage strengths of 80 mg, 120 mg, 160 mg, 5 mg/mL and 15 mg/mL.
Sotalol tablets are supplied as capsule-shaped tablets engraved with the brand name on one side and dosage strength on the other side. And each sotalol vial is individually packed in a carton.
The recommended initial adult dose for arrhythmias is sotalol 80 mg tablet orally twice daily. This dose may be adjusted gradually every 3 days in order to attain steady plasma concentration. The intravenous dose is almost equal to the oral dose and administered at the same frequency, 75 mg of intravenous sotalol is approximately equal to 80 mg of oral sotalol.
For children 2 years and older, the initial recommended dose for arrhythmia is sotalol 30 mg/m2 orally for every 8 hours and may be increased up to 180 mg/m2/day orally.
Sotalol can cause irregular heartbeats and for the first three days during sotalol administration patient has to be in facility where patient’s heart can be monitored.
Sotalol is recommended to store at 25° C (77° F) with excursion permitted to 15° C - 30° C (59° F - 86° F).
Wholesale Price of Sotalol
The cost for sotalol intravenous solution 15 mg/mL is around $ 1,911.26 for a supply of 10 milliliters with per unit cost comes at $ 191.13
The wholesale price of 80 mg sotalol oral tablet is approximately $ 25.25 - $ 78.63 for a quantity of 100 tablets with per unit cost available at the lowest price of approximately $ 0.25
The wholesale price of 120 mg sotalol oral tablet is approximately $ 31.38 for a set of 100 tablets with per unit cost comes at the lowest price of $ 0.31
The cost for 160 mg sotalol oral tablet is in between a price range of $ 36.63 - $ 73.72 for a supply of 100 tablets with per unit cost comes at $ 0.37 - $ 0.74
Sotalol - Mechanism of Action
Sotalol is a non-selective beta-adrenergic receptor and potassium channel antagonists. In the heart, sotalol inhibits inotropic and chronotropic effects thereby slowing the heart rate and decreases the myocardial contractility. Sotalol also slows down the conduction in the atria and in the atrioventricular node and increases the refractory period of the atrioventricular node. In the lungs, sotalol inhibits vasodilation and bronchodilator.
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