Somatostatin is a hormone which is produced by the hypothalamus and many different tissues such as pancreas and the gastrointestinal tract. It is found primarily in the nervous and digestive systems. Somatostatin is a growth hormone-inhibiting hormone. It is a naturally occurring peptide hormone that controls the endocrine system.
Somatostatin is used to treat severe watery diarrhea and sudden reddening / flushing of the face and neck in patients with tumors such as carcinoid, pancreatic islet cell tumors and vasoactive intestinal peptide-secreting tumors which are found in intestine and pancreas.
This drug is also used to treat acromegaly that occurs when the body produces too much growth hormone and the hands, feet, head grow too large.
Somatostatin is also indicated for the symptomatic treatment of acute bleeding from esophageal varices.
Manufacturers of Somatostatin market this drug under the Brand name of Stilamin, Somatosan. This medication is available in the form of Injection (solution, powder, lyophilized) and may be administered intravenously or subcutaneously or intramuscularly. Somatostatin Injections are available in dosage strength of 3 mg / 2 mL, 3 mg.
Somatostatin 20 mg. 40 mg and 60 mg, powder in a vial to be reconstituted with the provided 2mL diluent for injectable suspension. The injection must be reconstituted by a trained health care professional and it must be administered immediately after reconstitution. This medication for injectable suspension is supplied in a single use kit.
The initial recommended adult dose of Somatostatin for Acromegaly is 50 mcg, intravenously or subcutaneously, three times a day with a maximum dose of 500 mcg three times a day. This medication must start with a low dose which helps patients adapt to any adverse events.
The initial recommended adult dose of Somatostatin analogue for Acromegaly is 40 mg by intramuscular injection once every 4 weeks. The dose can be adjusted based on biochemical response and patient tolerability.
Somatostatin Injectable are stored at refrigerated temperature 2 C – 8 C (36 F – 46 F). At room temperature 20 C – 30 C (68 F – 86 F) the injectable is stable for 14 days if protected from light.
Wholesale Price of Somatostatin
In the US region the wholesale price for 50 mcg/mL Somatostatin injectable solution is around $ 71.73 for a supply of 25 milliliters with per unit cost available at as low as $ 2.87. The lowest
available price for 100 mcg/mL Somatostatin injectable solution is around $ 38.06 for a supply of 10 milliliters with per unit cost available at as low as approximately $ 3.81
Somatostatin - Mechanism of Action
Somatostatin is a hypothalamic peptide. It exhibits several biological roles but majorly exerts an inhibitory effect on secretion of other hormones and transmitters. Somatostatin is produced in the body by the hypothalamus. Somatostatin suppresses luteinizing hormone response to gonadotropin-releasing hormone, decreases splanchnic blood flow and inhibits the release of secretin, motilin, gastrin, serotonin, and pancreatic polypeptide which ultimately helps in controlling the symptoms of flushing and diarrhea in carcinoid tumors.
Somatostatin also mediates an analgesic activity by reducing vascular components of inflammation.
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