Sodium Picosulphate
Sodium Picosulfate is also known as sodium Picosulphate is a laxative and a contact stimulant.
It is used as a laxative for constipation or to prepare the large bowel before colonoscopy or
surgeries. Sodium Picosulfate provides relief from constipation, when the patient suffers
difficulty in emptying bowels, as a result of hardened feces. Sodium Picosulfate stimulates
muscles in the colon to remove waste products from the body while softening stools. It can
provide short-term relief from constipation caused by any issue or problem or cause.
Sodium picosulfate is sold under the brand names Sodipic, Picofast, Laxoberal among others.
Organon Nv filed the first patent related to Novel modified acid crystals and a process for their
preparation in 1969 in the UK.
Dosage and administration
Sodium picosulfate is available as tablets, delayed-release tablets, and solutions. For
Constipation, the oral adult dose is 5-10 mg, taken as a single dose, at night.
For children aged 1 month to <4 years, the recommended dose is 0.25 mg per kg, the dose for
4-10 years old is 5 mg for 2.5-5 mg, and for kids older than 10 years, the dose is 5-10 mg. To
achieve bowel evacuation for investigational procedures, the recommended dose is 10mg with
Mg citrate, taken in the morning and afternoon on the day prior to the examination.
The price of Sodium Picosulfate
In the USA, consumers pay around $170 for a supply of 320 milliliters oral solution for a 12 g-
3.5 g-10 mg per every160 mL. this medicine is significantly cheaper in developing parts of the
world. In India, the same supply of 10 tablets of 10mg, would cost the consumer between US$
0.30 to US$ 1.5 depending on the brand bought.
How Sodium Picosulfate works
Sodium Picosulfate is a laxative. As a laxative, it increases the movement of the intestines,
which results in the passage of stool. It is a prodrug, meaning, it has no significant direct
physiological effect on the intestine. It gets metabolized by gut bacteria into the active
compound 4,4'-dihydroxy diphenyl-(2-pyridyl)methane (DPM, BPHM). This compound is a
stimulant laxative and increases peristalsis in the gut. Sodium picosulfate is normally used with
magnesium citrate, an osmotic laxative, and has been found to be a highly effective laxative,
making it ideal for bowel cleansing prior to colonoscopies.
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