Silodosin
Silodosin, an alpha-blocker, is used to treat the symptoms of an enlarged prostate or benign
prostatic hyperplasia in men. This includes difficulty in urinating like hesitation, dribbling, weak
stream, and incomplete bladder emptying, painful urination, and urinary frequency and urgency.
Silodosin can only relieve the symptoms but does not cure them.
Silodosin is sold under the brand names Rapaflo, Urorec, Silotrif, and Silorel among others.
Kissei Pharmaceutical and Daiichi Sankyo received their first marketing approval in 2006 for
sale in Japan, under the brand name Urief. Later on, Kissei licensed the US, Canadian, and
Mexican rights to Watson Pharmaceuticals in 2004. It was approved by USFDA and Health
Canada approved under the brand name Rapaflo in 2008 and 2011 respectively.
Dosage and administration
Silodosin comes as a capsule. It is taken orally with food once a day and should not take on an
empty stomach. It should be taken around the same time every day and the users have to
continue even if they find relief from symptoms. The therapy should be stopped only in
consultation with the doctor. The recommended adult dose is 8 mg, taken orally, once a day
with meals. those with difficulty in swallowing pills and capsules are to open the RAPAFLO
capsule and sprinkle the powder inside on a tablespoonful of applesauce and swallowed
immediately or within 5 minutes without chewing. This should be followed by an 8 ounces’ glass
of cool water to ensure complete swallowing. The applesauce should be cool (not hot) and easy
to swallow. Any mixture should be used immediately and not stored for future use.
The Price of Silodosin
In the USA, the consumer has to pay an average retail price of $221.91 for 30 capsules of
generic brand of 8mg strength. The price of this medicine is much cheaper in the developing
world. In India, the cost of 10, 8mg capsules is around USD 2.6 and the 8mg tablet costs USD
2.7 and 8mg capsule USD 3 for a supply of 10 capsules.
How does it work?
Silodosin displays potent effects on α1A adrenergic receptors in the prostate, the bladder, and
the prostatic urethra. It exerts in action by relaxing the muscles of the bladder and prostate. It
can only control the symptoms of BPH but cannot cure it. It also cannot shrink the prostate. The
overall result is relief from symptoms like difficulty in beginning the flow of urine, weak stream,
and the need to urinate often or urgently. Patients with high blood pressure are advised against
using this medicine.
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