Selenium is a mineral that is found in soil and occurs naturally in certain foods like, whole grains, sunflower seeds, and seafood. The amount of selenium in food depends on where it is grown and raised.
Selenium belongs to the class of Trace Elements / Metals.
Selenium is a trace metal in the human body and most of the selenium in the body comes from the diet. The human body needs selenium for normal growth and health. Selenium is also needed for certain enzymes that help with normal body mechanisms.
Selenium is majorly indicated for the supplementation of total parenteral nutrition to prevent hypo selenium or selenium deficiency. Selenium has been used in alternative medicine as an aid to treat autoimmune disorders of the thyroid like Hashimoto’s thyroiditis. It is also used to treat high cholesterol.
Selenium is advised as a prescription product as well as the mixture product. It is also available as over the counter product.
Manufacturers market Selenium under the Brand name of Selenious Acid, Selenium TR, Selepen which is available in the dosage form of Tablet, Tablet (ER), Capsule and Injectable Solution. Tablet and Capsule are administered orally and Injectable Solution is given via intravenous route. This medication is supplied in a dosage strength of 50mcg, 100mcg, 125mcg, 200mcg, 40mcg/mL and 60mcg/mL
The recommended dietary allowances for male and female is 55 mcg/day, for pregnant women it is recommended to take 50 mcg/day and for lactating females the recommended dietary allowance is around 70 mcg/day.
For pediatric patients below 3 years, the recommended daily dose is 20 mcg/day.
Selenium injection is indicated in adults and pediatric patients as a source of selenium for parenteral nutrition when oral or enteral nutrition is insufficient, not possible, or contraindicated. The recommended dosage of selenium in adults is 60 mcg/day.
The recommended dosage of selenium in pediatric patients 7 kg and above is 2 mcg/kg/day which can be increased up to 60 mcg/kg/day, and pediatric patients less than 7 kg is 2 - 4 mcg/kg/day.
The concentration of selenium must be monitored regularly during the treatment.
Selenium tablet and capsule are recommended to store in a closed container at room temperature away from direct light and moisture. It should not be refrigerated.
Selenium Injections are to be stored between 20° C to 25° C (68° F - 77° F).
Wholesale Price of Selenium
The cost for selenium intravenous solution (40 mcg/mL) is around $ 397 for a supply of 250 milliliters with per unit cost available at as low as $ 1.59
The wholesale price of selenium intravenous solution (60 mcg/mL) costs around $ 1450 for a supply of 50 milliliters with per unit cost comes at a price of $ 29
Selenium - Mechanism of Action
Selenium primarily occurs in human body as seleno compounds, mostly selenoproteins such as glutathione peroxidase and thioredoxin reductase. These seleno compounds alone or in combination with vitamin E acts as antioxidant there by preventing blood clots by inhibiting platelet aggregation, strengthen the immune system. Seleno compounds also inhibit the induction of protein kinase C.
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