Roflumilast belongs to a class of medication called phosphodiesterase inhibitors. Roflumilast is indicated as a treatment to control and prevent symptoms caused by lung disease such as chronic obstructive pulmonary disease which includes bronchitis. The symptoms include wheezing and shortness of breath.
Roflumilast is advised as a prescription product as well as a generic prescription products.
Before using this medication, the risk of taking the drug must be weighed against the benefits it provides. It is always recommended to consult a physician before taking Roflumilast as this medication may interact with other drugs and may aggravate the adverse reactions.
Manufacturers market Roflumilast under the Brand name of Daliresp, Daxas, Libertek. Roflumilast is available in the dosage form of Tablet in dosage strength of 250 mcg and 500 mcg. Roflumilast tablet is taken by mouth, usually taken with or without food once a day. Each tablet is film coated and is supplied as white or off - white, round tablets engraved with first letter of brand name on one side and dosage strength on the other side.
The recommended dose of Roflumilast in adults is one 500 mcg tablet per day. Roflumilast is not recommended for pediatric patients as safety and efficacy have not been established and moreover chronic obstructive pulmonary disease does not generally occur in children.
This medication must be used regularly to show its response as it does not work immediately. After a 500-mcg dose, the bioavailability of Roflumilast is about 80% and attains maximum plasma concentration in 0.5 - 2 hours in fasting stage, and in fed state it is reduced by 40 % and time taken to reach maximum plasma concentration is increased by 1 hour.
The roflumilast tablet is recommended to store at 20° C to 25° C (68° F - 77° F), with excursion permitted to 15° C to 30° C (59° F - 86° F),
Wholesale Price of Roflumilast
In U.S, the cost for Roflumilast oral tablet 250 mcg is around $ 276 for a supply of 20 tablets, with per unit cost available at $ 13.80 and the cost for a set of 28 tablets is $ 382.56 with per unit cost comes at $ 13.66
The whole sale price of Roflumilast oral tablet 500 mcg is around $ 409.20 for a quantity of 30 tablets with per unit cost available for $ 13.64 and the price for a set of 90 tablets is $ 1208.60 with per unit cost available for as low as $ 13.43
Roflumilast is categorized under patient assistance programs where the medication is sponsored by pharmaceutical companies where the drug is provided for free or at discounted rates to low income or underinsured people who fulfill the eligibility requirement.
Roflumilast - Mechanism of Action
Roflumilast is a phosphodiesterase inhibitor, due to its selective inhibition it has the ability to exhibit potential anti-inflammatory and anti-modulatory effects in the pulmonary system. It is believed that the increased levels of intracellular cyclic AMP are responsible for the effectiveness of Roflumilast.
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