Phenylephrine

Phenylephrine is a medication primarily used as a decongestant, to dilate the pupil, to increase blood pressure, and to relieve hemorrhoids. Phenylephrine relieves nasal discomfort caused by colds, allergies, and hay fever. It is also used to relieve sinus congestion and pressure. While it is marketed as a decongestant, taken by mouth at recommended doses it is of unclear benefit for hay fever. When applied to the eye, it can treat uveitis and wide-angle glaucoma. It can also dilate the pupil of the eye. Phenylephrine sold under the brand names Sudafed PE Congestion, Neo-Synephrine, Biorphen, Nasop to name a few. Bayer pharma is the current assignee of one of the patents filed with the FDA and was granted the approval in 2015. Effects of phenylephrine were first described in the 1930s, and it was first used to maintain Blood Pressure during spinal anesthesia Phenylephrine was patented in 1927 and came into medical use in 1938. It is sold as a generic medication.

The price of Phenylephrine

In the United Kingdom the injectable formulation costs the NHS £4 per vial. In the USA, the consumers have to pay an average retail price of $9.07 for a supply of 36 tablets of 10 mg.

Dosage Forms & Strengths

Phenylephrine’s commercially sold formulations include nasal jelly, nasal drops, and nasal spray and as well as immediate release oral tablets or gelatin capsules. Phenylephrine can be taken by mouth, given by injection into a vein or muscle, or applied to the skin. While treating for Sinus Congestion, the recommended dose is 10 mg every 4 hours and with maximum dose not to exceed 60 mg per day. The treatment of Hypotension, Usual Adult Dose for Perioperative patients undergoing surgery is 50 to 250 mcg by intravenous bolus with a maintenance dose of 0.5 to 1.4 mcg per kg per min by intravenous continuous infusion. In treating for Shock, the usual adult dose for Perioperative dosing is 50 to 250 mcg by intravenous bolus with a maintenance dose is 0.5 to 1.4 mcg/kg. in the treating nasal congestion the Usual Adult Dose is 10 mg orally every 4 hours and the Pediatric Dose for Nasal Congestion in kids, 12 years and older is 10 mg orally every 4 hours.

How does Phenylephrine work?

Phenylephrine is a sympathomimetic drug. These drugs work by mimicking the actions of epinephrine also known as adrenaline or norepinephrine. Phenylephrine selectively binds to alpha-1 receptors causing blood vessels to constrict. Phenylephrine is used to get temporary relief from stuffy nose, sinus, and ear symptoms caused by the common cold, flu, allergies, or other breathing illnesses. It works by decreasing swelling in the nose and ears, thereby lessening discomfort and making it easier to breathe.

Finding Phenylephrine Manufacturers and Phenylephrine Suppliers

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