Olmesartan is a synthetic imidazole derivative that belongs to the family of drugs named angiotensin II receptor blocker (ARB) with antihypertensive activity. It works by blocking a substance in the body that causes the blood vessels to tighten, as a result, Olmesartan relaxes the blood vessels which in turn lowers the blood pressure and increases the supply of blood and oxygen to the heart. Lowering blood pressure can reduce the risk of strokes and heart attacks.
Olmesartan is used alone or together with other drugs to treat hypertension. Olmesartan is also used off-label for the management of Type 2 Diabetes-associated nephropathy, heart failure, and post-myocardial infarctions, particularly in patients who are unable to tolerate ACE inhibitors.
Olmesartan is advised as a prescription product, generic prescription product as well as mixture product.
Manufacturers of Olmesartan market these drugs under the Brand name of Benicar, Olmetac, Olmy, Olsar, Olvance, Erastapex, and WinXP. This drug is available only with the doctor’s prescription and it is available in the dosage form of Tablet which is administered orally. Olmesartan is available in varied dosage strengths – 5mg, 10mg, 20mg, and 40mg in white/oval shaped film-coated tablets. The recommended starting dose of Olmesartan is 10mg once daily but in patients whose blood pressure level is not adequately maintained at this dose, the dose may be increased to 20mg once daily.
Olmesartan can be taken with or without food and one should keep using this drug as directed by the physician and even when one feels well. Often High Blood Pressure has no symptoms and one may need to use this drug for the rest of the life.
Within 2 weeks of initiating therapy, the antihypertensive effect of Olmesartan is substantially visible and will reach a maximum by about 8 weeks after initiating therapy. One has to bear in mind when considering changing the dose regimen.
The approved storage conditions for Olmesartan are “Do not store above 25 C (77 F) and store in the original container to protect from moisture.
Wholesale Price of Olmesartan
Olmesartan is a conservatively priced drug. The price of Olmesartan is around $18.93 for 30 tablets and is also available for the price as low as $11.03 for 30 tablets in the US. In Canada, the 20mg Olmesartan tablets are available at the price range of $140.99 for the quantity 90 tablets, and the generic version are available at as low as $69.99 for 100 tablets and 40mg at $84.99 for 100 tablets.
Olmesartan - Mechanism of Action
Olmesartan belongs to the Angiotensin II receptor blocker (ARB) family of drugs. Olmesartan selectively binds to angiotensin receptor 1 (AT1) and prevents the protein angiotensin II from binding. This prevents angiotensin II-induced vasoconstriction, stimulation, and synthesis of aldosterone and anti-diuretic hormone (ADH), thereby decreasing the aldosterone production and preventing aldosterone-stimulated sodium retention and potassium excretion.
Overall, Olmesartan’s physiologic effects lead to reduced blood pressure, lowers aldosterone levels, reduced cardiac activity, and increased excretion of sodium.
Olmesartan also affects the renin-angiotensin aldosterone system, plays an important role in hemostasis and regulation of kidney, vascular and cardiac function.
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