Neomycin belongs to the class of antibiotics and it is used to reduce the risk of infection during surgery of the bowel. Neomycin is also used to reduce the symptoms of hepatic coma.
Neomycin has been shown to be an effective adjunctive therapy in a hepatic coma by reduction of the ammonia forming bacteria in the intestinal tract. Neomycin is also combined with oral erythromycin or metronidazole and given in addition to intravenous prophylaxis.
Before using this medication, the risk of taking the drug must be weighed against the benefits it provides. It is always recommended to consult a physician before taking neomycin as this medication may interact with other drugs and health problems.
Neomycin is Marketed with the brand name Myacyne, Mycifradin, Myciguent, Neo-Rx, Neobiotic, and Nivemycin. Neomycin is advised as a prescription product and generic prescription product.
This medication is available in dosage form of Tablet and Solution which are available in dosage strengths of 500 mg /1, 87.5 mg/5mL.
Neomycin tablets, USP, for oral administration, contain neomycin which is an antibiotic obtained from the metabolic products of the actinomycete streptomyces radiate. Neomycin Tablets are taken orally in doses of 4-12 grams of Neomycin tablets per day (eight to 24 tablets) in divided doses. Treatment should be continued over a period of five to six days, during which time protein should be returned incrementally to the diet. Neomycin Tablets, USP, 500 mg (equivalent to 350 mg of neomycin base per tablet) are available as round, off-white, unscored tablets, debossed “500” and “PT”.
Neomycin oral solution is available as a clear orange solution available in bottles.
The usual recommended adult dose of neomycin drug for Hepatic Encephalopathy and Hepatic Coma is 4 to 12 grams orally per day which is taken in divided doses for a duration of 5 to 6 days. Before starting the treatment, protein should be withdrawn from the diet and diuretic agents should be avoided.
The usual pediatric dose of neomycin for bowel preparation is 15 mg/kg orally given which is divided into 3 doses and administered over 10 hours approximately before the operation and after the mechanical bowel preparation.
Neomycin Oral solution formulations are recommended to be stored at 20° C to 25° C (68° F - 77° F).
Wholesale Price of Neomycin
The lowest available price for neomycin 500 mg is around $7.06 for a supply of 6 tablets.
Neomycin - Mechanism of action
Neomycin is active against both gram-positive and gram-negative organisms, including the major E. coli species resident in the colon as well as the enteropathogenic forms of E. coli. Neomycin bactericidal in action. Like other aminoglycosides, neomycin inhibits bacterial protein synthesis through irreversible binding to the 30 S ribosomal subunit of susceptible bacteria. Neomycin is actively transported into the bacterial cell where it binds to receptors present on the 30 S ribosomal subunit. The bacterial translation is normally initiated by the mRNA binding to the 30S ribosomal subunit and subsequent binding with the 50S subunit for elongation. Neomycin is poorly absorbed from the gastrointestinal tract. Gastrointestinal absorption of the drug may be increased if the inflammatory or ulcerative gastrointestinal disease is present.
Finding Neomycin Manufacturers and Suppliers
To find an honest partner in our business is one of the big tests and to defeat that test and to make one’s work/life easy in finding the honest manufacturer and supplier of neomycin one can visit the Pipelinepharma website which helps the buyer in finding the dependable manufacturers and suppliers of neomycin. Pipelinepharma, which is a business-to-business (B2B) licensing marketplace for pharmaceutical products, quickly connects the proprietor with the consumers for business development.
The buyer can filter the product names in user familiar and unified search engine by its country, category, therapeutic area, forms, dossier, and its status, regulatory filings, approvals, and more.