Loxoprofen sodium belongs to the propionic acid derivatives group. It is a nonsteroidal anti-
inflammatory drug much like ibuprofen and naproxen. Loxoprofen sodium reduces inflammation
and pain in patients suffering from rheumatoid arthritis, osteoarthritis, lumbar pain, frozen
shoulder, neck-shoulder-arm syndrome, tooth pain, as well as after surgery, wounds, or tooth
Loxoprofen sodium is marketed in Brazil, Mexico, and Japan Loxonin, in Argentina as Oxeno
and in India as Loxomac among others. It is also sold as a drug for oral use in some countries.
Sankyo received approval for a transdermal preparation for sale in Japan in 2006, followed by
tape and gel formulations in 2008 and 2010 respectively. Sankyo Company Limited patented it
in 1977 and approved it for medical use in the USA in1986.
Dosage and administration
Loxoprofen sodium is available as tablets of 60mg and transdermal patches. The usual
recommended adult dose is one 60 mg tablet, taken orally at a time, 3 times a day. This
medicine should be taken with food or immediately after meals.
The price of Loxoprofen sodium
In Japan, the consumer has to pay between US$24.49 for a supply of 100, 60mg tablets. In the
API market, the medicine grade powder of Loxoprofen sodium costs around USD160 per kilo.
How does it work?
Loxoprofen sodium is an NSAID b
ut a prodrug. It has similar actions to other NSAIDs. It non-
selectively inhibits cyclooxygenase and reduces the synthesis of prostaglandins from
arachidonic acid. 3 Cyclooxygenase found in 2 forms, COX-1 and COX-2, serve different
functions. COX-1 is constitutively released and is involved in cellular housekeeping functions
like mucus production and platelet aggregation. COX-2 is induced in cells after an injury or due
to other stimuli and appears in large quantities in the injury site or stimuli. They are responsible
for mediating inflammation and pain. By inhibiting COX isoforms, it reduces the expression of
several mediators of pain, inflammation, and fever.
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